79741-43-8

Basic information

• Product Name: 8-phenyl-1,4-dioxaspiro[4.5]decan-8-amine
• Synonyms: 8-phenyl-1,4-dioxaspiro[4.5]decan-8-amine
• CAS NO: 79741-43-8
• Molecular Weight: 233.31
• Mol File: 79741-43-8.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 8-phenyl-1,4-dioxaspiro[4.5]decan-8-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 8-phenyl-1,4-dioxaspiro[4.5]decan-8-amine(79741-43-8)
• EPA Substance Registry System: 8-phenyl-1,4-dioxaspiro[4.5]decan-8-amine(79741-43-8)

Safety Data

• Hazardous Substances Data: 79741-43-8(Hazardous Substances Data)

Upstream product

• 100-58-3 phenylmagnesium bromide 
• 94112-58-0 4-hydroxy-4-phenyl-cyclohexanone ethylene ketal 
• 1195178-97-2 8-azido-8-phenyl-1,4-dioxaspiro[4.5]decane 
• 861857-71-8 2-methyl-propane-2-sulfinic acid (1,4-dioxa-spiro[4.5]dec-8-ylidene)-amide 
• 4746-97-8 cyclohexanedione monoethylene ketal 

Downstream Products

• 95261-39-5 4-amino-4-phenylcyclohexan-1-one 
• 1195179-05-5 1-(4-(2-methylpyridin-4-yl)phenyl)-3-(4-oxo-1-phenylcyclohexyl)urea 
• 1195173-44-4 1-(4-hydroxy-1-phenylcyclohexyl)-3-(4-(2-methylpyridin-4-yl)phenyl)urea 
• 1195173-47-7 1-(4,4-difluoro-1-phenylcyclohexyl)-3-(4-(2-methylpyridin-4-yl)phenyl)urea 
• 1195179-01-1 1-(4-(2-methylpyridin-4-yl)phenyl)-3-(8-phenyl-1,4-dioxaspiro[4.5]decan-8-yl)urea 

Relevant articles and documents

Enantioselective Silver and Amine Co-catalyzed Desymmetrizing Cycloisomerization of Alkyne-Linked Cyclohexanones

A silver(I) and amine co-catalyzed desymmetrization of 4-propargylamino cyclohexanones for the direct enantioselective synthesis of 2-azabicyclo[3.3.1]nonanes is described. Exploiting reactivity arising from dual activation of the pendant terminal alkyne by silver(I) and the ketone moiety through transient enamine formation, this synthetically relevant transformation is easy to perform, efficient and broad in scope. High enantioselectivity (up to 96 % ee) was achieved by exploiting a significant matching effect between the chirality of a cinchona alkaloid-derived aminophosphine ligand for the silver(I) salt and the 2-bis(aryl)methylpyrrolidine catalyst which was rationalized by DFT calculations. This allowed for the preparation of both enantiomers of the bicyclic product with near-identical stereocontrol.

UREA COMPOUNDS AS GAMMA SECRETASE MODULATORS

The present invention provides compounds Formula (I) that are gamma secretase modulators and are therefore useful for the treatment of diseases treatable by modulation of gamma secretase such as Alzheimer's disease. Also provided are pharmaceutical compositions containing such compounds and processes for preparing such compounds.