79751-06-7Relevant articles and documents
A simple synthesis of polyfunctionalized 4-aminopyrazolidin-3-ones as 'aza-deoxa' analogs of D-cycloserine
Novak, Ana,Stefanic, Matej,Groselj, Uros,Hrast, Martina,Kasunic, Marta,Gobec, Stanislav,Stanovnik, Branko,Svete, Jurij
, p. 245 - 267 (2014/03/21)
A simple five-step synthesis of fully substituted (4RS,5RS)-4- aminopyrazolidin-3-ones as analogs of D-cycloserine was developed. It comprises a two-step preparation of 5-substituted (4RS,5RS)-4-(benzyloxycarbonylamino) pyrazolidin-3-ones, reductive alkyl
Amino Acids, 16. - Synthesis of N-Acyl-2,3-didehydro-2-amino Acid Esters
Effenberger, Franz,Kuehlwein, Juergen,Drauz, Karlheinz
, p. 1295 - 1302 (2007/10/02)
N-Acyl-2,3-didehydro-2-amino acid esters 3, 5, 7-12, with a great variety of N-substituents, are obtained in good yields by the perrhenate-catalyzed decomposition of methyl 2-azido carboxylates 1 in organic solvents in the presence of the corresponding acyl chlorides 2.By using methyl 2-azido-isovalerate (1a), the conditions (catalyst, solvent, temperature) for the reaction to give 3a were optimized.The reactivity of acyl chlorides can be strongly enhanced with equimolar amounts of dimethyl formamide, which allows a lowering of the decomposition temperature for this reaction.Under these mild reaction conditions also the unstable N-acyldehydroalanine derivative 5f can be obtained in good yield. - Key Words: 2-Azidocarboxylates/ Rhenium catalysts/ Amino acids
Dehydrooligopeptides. XII. Convenient synthesis of various kinds of N-benzyloxycarbonyl-α-dehydroamino acid methyl esters
Shin,Takahashi,Yonezawa
, p. 2020 - 2023 (2007/10/02)
-
