79757-20-3

Basic information

• Product Name: Tert-butyl 2-(pyridin-4-yl)acetate
• Synonyms: Tert-butyl 2-(pyridin-4-yl)acetate
• CAS NO: 79757-20-3
• Molecular Formula: C₁₁H₁₅NO₂
• Molecular Weight: 193.2423
• Mol File: 79757-20-3.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: Tert-butyl 2-(pyridin-4-yl)acetate(CAS DataBase Reference)
• NIST Chemistry Reference: Tert-butyl 2-(pyridin-4-yl)acetate(79757-20-3)
• EPA Substance Registry System: Tert-butyl 2-(pyridin-4-yl)acetate(79757-20-3)

Safety Data

• Hazardous Substances Data: 79757-20-3(Hazardous Substances Data)

Upstream product

• 540-88-5 acetic acid tert-butyl ester 
• 26156-84-3 N-tritylpyridinium tetrafluoroborate 
• 79756-97-1 (2',6'-Dimethyl-4'-oxo-4H,4'H-[1,1']bipyridinyl-4-yl)-acetic acid tert-butyl ester 
• 1120-87-2 4-bromopyridin 
• 51656-70-3 (2-tert-butoxy-2-oxoethyl)zinc(II) bromide 
• 107-59-5 tert-Butyl chloroacetate 

Downstream Products

• 28356-58-3 pyridine-4-acetic acid 
• 115-11-7 isobutene 

Relevant articles and documents

Palladium-catalyzed α-arylation of zinc enolates of esters: Reaction conditions and substrate scope

The intermolecular α-arylation of esters by palladium-catalyzed coupling of aryl bromides with zinc enolates of esters is reported. Reactions of three different types of zinc enolates have been developed. α-Arylation of esters occurs in high yields with i

Palladium-catalyzed α-arylation of esters and amides under more neutral conditions

Two procedures for the ∞-arylation of carbonyl compounds under conditions that are more neutral than those of reactions of aryl halides with alkali metal enolates are reported. The first procedure rests upon the development of catalysts bearing the hindered pentaphenylferrocenyl di-tert-butylphosphine (Q-phos) and the highly reactive dimeric Pd(I) complex {P(t-Bu)3]PdBr}2. By this procedure, zinc enolates prepared from ∞-bromo esters and amides react with aryl halides to form ∞-aryl esters and amides in high yields under mild conditions with 1-2 mol % catalyst and with remarkable functional group tolerance. By the second procedure, silyl ketene and silyl ketimine acetals react with aryl bromides in the presence of substoichiometric zinc fluoride, 1 mol % Pd(dba)2, and 2 mol % P(t-Bu)3 in DMF solvent at 80 °C. Reactions of zinc tert-butyl acetate and propionate enolates and trimethylsilyl ketene acetals of tert-butyl propionate and methyl isobutyrate with aryl bromides bearing electron-donating and potentially reactive, base-sensitive electron-withdrawing groups and with pyridyl bromides are reported. In addition, the diastereoselective coupling of phenyl bromide with an imide enolate bearing the Evans auxiliary is reported, and this study shows that racemization of base-sensitive stereocenters does not occur during the coupling process under these more neutral conditions. Copyright