798543-46-1

Basic information

• Product Name: 3-[1-(2,4-dimethoxybenzyl)-2-oxo-1,2,5,6-tetrahydropyridin-3-yl]propionic acid methyl ester
• Synonyms: 3-[1-(2,4-dimethoxybenzyl)-2-oxo-1,2,5,6-tetrahydropyridin-3-yl]propionic acid methyl ester
• CAS NO: 798543-46-1
• Molecular Weight: 333.384
• Mol File: 798543-46-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 3-[1-(2,4-dimethoxybenzyl)-2-oxo-1,2,5,6-tetrahydropyridin-3-yl]propionic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3-[1-(2,4-dimethoxybenzyl)-2-oxo-1,2,5,6-tetrahydropyridin-3-yl]propionic acid methyl ester(798543-46-1)
• EPA Substance Registry System: 3-[1-(2,4-dimethoxybenzyl)-2-oxo-1,2,5,6-tetrahydropyridin-3-yl]propionic acid methyl ester(798543-46-1)

Safety Data

• Hazardous Substances Data: 798543-46-1(Hazardous Substances Data)

Upstream product

• 5621-44-3 dimethyl 2-methylenepentanedioate 
• 3621-79-2 2-methyleneglutaric acid 
• 798543-44-9 N-(but-3-enyl)-(2,4-dimethoxybenzyl)amine 
• 93633-32-0 5-methoxy-2-methylene-5-oxopentanoic acid 

Downstream Products

• 798543-63-2 3-[1-(4-acetylamino-benzyl)-2-oxo-1,2,5,6-tetrahydro-pyridin-3-yl]-N-hydroxy-propionamide 
• 798543-65-4 3-[1-(4-acetylamino-benzyl)-2-oxo-1,2,5,6-tetrahydro-pyridin-3-yl]-propionic acid methyl ester 
• 798543-72-3 N-hydroxy-3-(2-oxo-1-phenethyl-piperidine-3-yl)-propionamide 
• 798543-64-3 3-[1-(4-amino-benzyl)-2-oxo-1,2,5,6-tetrahydro-pyridin-3-yl]-propionic acid methyl ester 

Relevant articles and documents

Structure-activity relationship studies of a series of novel δ-lactam-based histone deacetylase inhibitors

We synthesized a series of δ-lactam-based HDAC inhibitors that were identified with various degrees of anti-inflammatory and cell growth inhibitory activities. Compounds possessing significant HDAC inhibitory activity exhibited both anti-inflammatory and cell growth inhibitory activities as well as significant tumor growth inhibition in the in vivo tumor xenograft experiments. Besides, these compounds demonstrated antiinflammatory properties in vitro via suppression of the production of the proinflammatory cytokine TNF-α and nitric oxide by LPS-stimulated RAW264.7 cells.

NOVEL 2-OXO-HETEROCYCLIC COMPOUNDS AND THE PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME

The present invention is related to new 2-oxo-cyclic compound the process for preparing them and a pharmaceutical composition comprising the same. The present invention provides a pharmaceutical composition for preventing and treating the inflammatory