79867-80-4

Basic information

• Product Name: N-cyclohexyldaunorubicin
• CAS NO: 79867-80-4
• Molecular Weight: 609.673
• Mol File: 79867-80-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-cyclohexyldaunorubicin(CAS DataBase Reference)
• NIST Chemistry Reference: N-cyclohexyldaunorubicin(79867-80-4)
• EPA Substance Registry System: N-cyclohexyldaunorubicin(79867-80-4)

Safety Data

• Hazardous Substances Data: 79867-80-4(Hazardous Substances Data)

Upstream product

• 108-94-1 cyclohexanone 
• 23541-50-6 daunomycin hydrochloride 

Relevant articles and documents

Enhanced Antitumor Properties of 3'-(4-Morpholinyl) and 3'-(4-Methoxy-1-piperidinyl) Dervatives of 3'-Deaminodaunorubicin

Reductive N,N-dialkylation of daunorubicin with 2,2'-oxydiacetaldehyde and NaBH3CN occurred in two steps without interruption and with cyclization to form 3'-(4-morpholinyl)-3'-deaminodaunorubicin.This derivative retained the antitumor efficacy of doxorubicin against mouse leukemia P388 but at one-fortieth the dose; hence, it is the most potent anthracycline analogue synthesized so far.The 4-methoxy-1-piperidinyl derivative, similarly prepared with 3-methoxyglutaraldehyde, showed improved efficacy against P388, though at normal doses.Results with a series of analogues indicate that incorporation of the N in the new ring and the presence of an ether O at the 4-position are critical for enhanced activity.