79896-31-4

Basic information

• Product Name: (1S,4R) Sertraline Hydrochloride
• Synonyms: (1S,4R) Sertraline Hydrochloride;(1S-trans)-4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1- -naphthalenamine Hydrochloride;(1S,4R)-Sertraline HCl
• CAS NO: 79896-31-4
• Molecular Formula: C₁₇H₁₇Cl₂N*ClH
• Molecular Weight: 342.69
• Product Categories: Chiral Reagents;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 79896-31-4.mol
• Article Data: 4

Chemical Properties

• Melting Point: 258-260°C
• Appearance: /
• Storage Temp.: -20?C Freezer
• CAS DataBase Reference: (1S,4R) Sertraline Hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: (1S,4R) Sertraline Hydrochloride(79896-31-4)
• EPA Substance Registry System: (1S,4R) Sertraline Hydrochloride(79896-31-4)

Safety Data

• Hazardous Substances Data: 79896-31-4(Hazardous Substances Data)

Usage

Chemical Properties

White Solid

Uses

Enantiomer 1S,4R of Sertraline. Antidepressant

Upstream product

• 91797-60-3 trans-(1S,4R)-N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenamine 

Relevant articles and documents

Concise enantioselective synthesis of (+)-sertraline and (-)-CP-52002 using proline catalysis

A short enantioselective synthesis of (+)-sertraline and its C4 epimer (-)-CP-52002 with an overall yield of 30%, respectively, as its hydrochloride has been described. The key steps are the proline catalyzed Mannich reaction of acetaldehyde and acid catalyzed intramolecular Friedel-Crafts' alkylation reaction of olefin proceeding with high optical purities.

PROCESSES FOR PREPARING SERTRALINE

Provided are processes for the preparation of sertraline and sertraline hydrochloride.