79917-01-4Relevant articles and documents
Controlled Single and Double Iodofluorination of Alkynes with DIH- and HF-Based Reagents
Pfeifer, Lukas,Gouverneur, Véronique
, p. 1576 - 1579 (2018)
A novel protocol for the regio- and stereoselective iodofluorination of internal and terminal alkynes using 1,3-diiodo-5,5,-dimethylhydantoin and HF-based reagents is disclosed. This approach is used to prepare a fluorinated tamoxifen derivative in two steps from commercially available starting materials. A facile method enabling controlled regioselective double iodofluorination of terminal alkynes is also presented.