79955-35-4 Usage
Description
1-(2-fluoroethyl)-3-(2-hydroxyethyl)-1-nitrosourea is a synthetic chemical compound that belongs to the nitrosourea class of alkylating agents. It is characterized by its ability to cross the blood-brain barrier, making it a valuable agent in cancer chemotherapy, particularly for the treatment of brain tumors. 1-(2-fluoroethyl)-3-(2-hydroxyethyl)-1-nitrosourea works by alkylating DNA, which disrupts DNA replication and leads to cell death. However, it also has toxic effects on healthy tissues, such as the bone marrow and gastrointestinal tract, necessitating careful dosing and monitoring in cancer treatment.
Uses
Used in Cancer Chemotherapy:
1-(2-fluoroethyl)-3-(2-hydroxyethyl)-1-nitrosourea is used as an anticancer agent for the treatment of brain tumors. Its ability to cross the blood-brain barrier allows it to target cancer cells in the brain effectively. It functions by alkylating DNA, disrupting DNA replication, and ultimately leading to cell death.
Used in Pharmaceutical Research:
Due to its alkylating properties and potential applications in cancer treatment, 1-(2-fluoroethyl)-3-(2-hydroxyethyl)-1-nitrosourea is also used as a research compound in the development of new pharmaceuticals and therapies for various types of cancer.
Used in Drug Delivery Systems:
To mitigate the toxic effects on healthy tissues and improve the therapeutic outcomes of 1-(2-fluoroethyl)-3-(2-hydroxyethyl)-1-nitrosourea, it can be incorporated into novel drug delivery systems. These systems may include various organic and metallic nanoparticles as carriers, aiming to enhance the compound's delivery, bioavailability, and efficacy against cancer cells while minimizing side effects on healthy tissues.
Check Digit Verification of cas no
The CAS Registry Mumber 79955-35-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,9,9,5 and 5 respectively; the second part has 2 digits, 3 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 79955-35:
(7*7)+(6*9)+(5*9)+(4*5)+(3*5)+(2*3)+(1*5)=194
194 % 10 = 4
So 79955-35-4 is a valid CAS Registry Number.
79955-35-4Relevant articles and documents
Studies on Synthesis and Anticancer Activity of Selected N-(2-Fluoroethyl)-N-nitrosoureas
Johnston, Thomas P.,Kussner, Conrad L.,Carter, Ronald L.,Frye, Jerry L.,Lomax, Nancita R.,et al.
, p. 1422 - 1426 (2007/10/02)
An activated carbamate, 2-nitrophenyl (2-fluoroethyl)nitrosocarbamate (3), was used to advantage in the synthesis of the water-soluble (2-fluoroethyl)nitrosoureas 6a-d from 2-aminoethanol, (1α,2β,3α)-2-amino-1,3-cyclohexanediol, cis-2-hydroxycyclohexanol, and 2-amino-2-deoxy-D-glucose.In a variation of this method, 2,4,5-trichlorophenyl (2-fluoroethyl)carbamate (4) was used to prepare the urea from which the essentially water-insoluble N'-(2,6-dioxo-3-piperidinyl)-N-(2-fluoroethyl)-N-nitrosourea (6e) was derived.The anticancer activity of these nitrosoureas was determined against the murine tumors B16 melanoma and Lewis lung carcinoma and found to be significant and comparable to their chloroethyl counterparts.On the basis of results from both systems, the dihydroxycyclohexyl derivative 6b may be the most effective.
