79982-83-5

Basic information

• Product Name: (2S,5S)-2,5-bis(phenylmethyl)piperazine
• Synonyms: (2S,5S)-2,5-bis(phenylmethyl)piperazine
• CAS NO: 79982-83-5
• Molecular Weight: 266.386
• Mol File: 79982-83-5.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: (2S,5S)-2,5-bis(phenylmethyl)piperazine(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,5S)-2,5-bis(phenylmethyl)piperazine(79982-83-5)
• EPA Substance Registry System: (2S,5S)-2,5-bis(phenylmethyl)piperazine(79982-83-5)

Safety Data

• Hazardous Substances Data: 79982-83-5(Hazardous Substances Data)

Upstream product

• 3081-24-1 H-Phe-OEt 
• 74134-64-8 3,6-dibenzyl-2-hydroxypyrazine 
• 114362-41-3 (3R,6R)-3,6-Dibenzyl-piperazin-2-one 
• 74134-77-3 2,5-dibenzylpyrazine 
• 2862-51-3 (3S,6S)-3,6-dibenzylpiperazine-2,5-dione 
• 123-91-1 1,4-dioxane 
• 69897-47-8 (S)-2-hydroxy-3-phenyl-propionamide 
• 3182-95-4 L-Phenylalaninol 
• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 
• 7524-50-7 methyl (2S)-2-amino-3-phenylpropanoate hydrochloride 
• 13082-29-6 L-phenylalanyl-L-phenylalanine methyl ester 
• 13122-89-9 (S)-methyl 2-((S)-2-(tert-butoxycarbonylamino)-3-phenylpropanamido)-3-phenylpropanoate 

Downstream Products

• 1609286-85-2 (1S,2S,4S,5S)-2,5-dibenzyl-1-methyl-4-aza-1-azoniabicyclo[2.2.2]octane trifluoromethanesulfonate 
• 1609286-83-0 (1R,2S,4R,5S)-2,5-dibenzyl-1-methyl-4-aza-1-azoniabicyclo[2.2.2]octane trifluoromethanesulfonate 
• 141804-57-1 (1S,2S,4S,5S)-2,5-bis(phenylmethyl)-1,4-diazabicyclo[2.2.2]octane 
• 141804-57-1 (2S,5S)-2,5-bis(phenylmethyl)-1,4-diazabicyclo<2.2.2>octane 
• 81536-08-5 (2S,5S)-1,4-dimethyl-2,5-bis(phenylmethyl)piperazine 
• 141804-54-8 (2S,5S)-2,5-Dibenzyl-4-methoxycarbonylmethyl-piperazine-1-carboxylic acid tert-butyl ester 
• 141804-56-0 (2S,5S)-2,5-Dibenzyl-4-(2-chloro-ethyl)-piperazine-1-carboxylic acid tert-butyl ester 
• 141804-55-9 (2S,5S)-2,5-Dibenzyl-4-(2-hydroxy-ethyl)-piperazine-1-carboxylic acid tert-butyl ester 
• 114409-89-1 (S)-2-Benzyl-1-[(2S,5S)-2,5-dibenzyl-4-((S)-2-benzyl-hexanoyl)-piperazin-1-yl]-hexan-1-one 
• 114409-84-6 (2S,5S)-2,5-dibenzyl-1,4-bis(3-phenylpropanoyl)piperazine 
• 114409-85-7 (2S,5S)-2,5-dibenzyl-1,4-dipropanoylpiperazine 
• 141804-53-7 (2S,5S)-2,5-Dibenzyl-piperazine-1-carboxylic acid tert-butyl ester 

Relevant articles and documents

SYNTHESIS OF (2S,5S)-2, 5-BIS(PHENYLMETHYL)PIPERAZINE BY THE REDUCTION WITH SODIUM BOROHYDRIDE USING TITANIUM TETRACHLORIDE

Optically active piperazine 1 is synthesized in relatively high yield by the reduction of cyclo-L-Phe-L-Phe with sodium borohydride-titanium tetrachloride

Preventing Candida albicans biofilm formation using aromatic-rich piperazines

The global increase in microbial resistance is an imminent threat to public health. Effective treatment of infectious diseases now requires new antimicrobial therapies. We report herein the discovery of aromatic-rich piperazines that inhibit biofilm forma

Novel chiral N,N′-dimethyl-1,4-piperazines with metal binding abilities

With the objective of developing novel chiral ligands, we report an efficient strategy to prepare chiral N,N-dimethyl-1,4-piperazines, six-member heterocyclic molecules that possess metal binding features. We prepared and characterized 18 piperazines, and evaluated their ability to complex different mono- and divalent metals, using a rapid picrate extraction technique. Some newly prepared diamine ligands were used in diethylzinc alkylation of aryl aldehydes. Yields increased significantly in the presence of the diamine ligands, though enantioselectivity was low. The results demonstrate the validity of the approach for preparing and identifying useful chiral diamine ligands.