80-74-0

Basic information

• Product Name: SULFISOXAZOLE ACETYL (200 MG)
• Synonyms: SULFISOXAZOLE ACETYL (200 MG);Acetamide, N-[(4-aminophenyl)sulfonyl]-N-(3,4-dimethyl-5-isoxazolyl)-;Acetyl sulfisoxazole;Lipo Gantrisin;N-(3,4-Dimethyl-5-isoxazolyl)-N-sulfanilylacetamide;n-3,4-dimethylisoxazol-5-yl-n-sulfanilylacetamide;N-Acetyl-4-amino-N-(3,4-dimethyl-5-isoxazolyl)benzenesulfonamide;Sulfisoxazole Acetyl
• CAS NO: 80-74-0
• Molecular Formula: C₁₃H₁₅N₃O₄S
• Molecular Weight: 309.3409
• EINECS: 201-305-3
• Mol File: 80-74-0.mol
• Article Data: 1

Chemical Properties

• Melting Point: 193-194°
• Boiling Point: 538.1±60.0 °C(Predicted)
• Appearance: /
• Density: 1.3541 (rough estimate)
• Refractive Index: 1.6320 (estimate)
• PKA: -0.17±0.10(Predicted)
• Water Solubility: 80mg/L(37 oC)
• CAS DataBase Reference: SULFISOXAZOLE ACETYL (200 MG)(CAS DataBase Reference)
• NIST Chemistry Reference: SULFISOXAZOLE ACETYL (200 MG)(80-74-0)
• EPA Substance Registry System: SULFISOXAZOLE ACETYL (200 MG)(80-74-0)

Safety Data

• Hazardous Substances Data: 80-74-0(Hazardous Substances Data)

Usage

Originator

Gantrisin Acetyl ,Roche ,US ,1954

Uses

Different sources of media describe the Uses of 80-74-0 differently. You can refer to the following data:
1. Sulfisoxazole Acetyl is an antibiotic used in the prevention of infection especially when used in conjunction with erythromycin.
2. Antibacterial.

Manufacturing Process

267 grams (1 mol) of sulfisoxazole were suspended in 400 ml of acetone and 79 grams (1 mol) of dry pyridine at 20-25°C in a round-bottom flask equipped with a stirrer and thermometer. 132 grams (1 mol) of acetic anhydride were added within 3 minutes with stirring. The sulfisoxazole dissolved in the mixture and a clear solution resulted. The temperature rose to 39-40°C. After stirring for several minutes, the product started to crystallize as a white crystalline mush. The temperature rose to 42-43°C maintained itself at this temperature for 15-30 minutes, and then started to drop. Stirring was continued for 5 hours and the mixture was then allowed to stand for 10 hours. One liter of 2.5-3.0% ice-cold aqueous ammonia and some fresh ice were then added while stirring and the crystals were filtered without delay. The crystals were washed on the filter with 1 liter of ice-cold 1% ammonia and then with 1 liter of water. The material on the filter was well pressed off, washed with 200-300 ml of alcohol and dried at 70°C to constant weight. The N-monoacetyl sulfisoxazole melted at 193-194°C and showed a positive Bratton-Marshall reaction and a positive Hucknall-Turfat reaction. The product is in the form of colorless crystals which are somewhat water repellent. It is insoluble in alkali but is saponified upon standing in alkaline suspension (3% ammonia). It is soluble in strong acids (20-36% HCl or 10 N H2SO4) and is rapidly saponified upon standing.

General Description

Sulfisoxazole acetyl shares the actions and usesof the parent compound, sulfisoxazole. The acetyl derivativeis tasteless and, therefore, suitable for oral administration, especiallyin liquid preparations. The acetyl compound is splitin the intestinal tract and absorbed as sulfisoxazole; that is, itis a prodrug for sulfisoxazole.

InChI:InChI=1/C13H15N3O4S/c1-8-9(2)15-20-13(8)16-21(18,19)12-6-4-11(5-7-12)14-10(3)17/h4-7,16H,1-3H3,(H,14,17)

Upstream product

• 127-69-5 sulfisoxazole 
• 108-24-7 acetic anhydride 

Downstream Products

• 15019-07-5 N-(3,4-dimethyl-isoxazol-5-yl)-N-(4-xanthen-9-ylamino-benzenesulfonyl)-acetamide 

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