80012-47-1 Usage
Chemical class
Imidazobenzodiazepine derivatives
Potential pharmacological properties
Psychoactive drug, anticonvulsant, anxiolytic agent
Research and medical applications
Used in various research and medical applications
Effects
Similar to benzodiazepines
Potential therapeutic applications
Treatment of mood disorders, anxiety, and insomnia
Salt form
Hydrochloride salt for increased stability and solubility in aqueous solutions
Field of interest
Pharmacology
Compound of interest
Yes, due to its potential therapeutic applications and pharmacological properties
Check Digit Verification of cas no
The CAS Registry Mumber 80012-47-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,0,0,1 and 2 respectively; the second part has 2 digits, 4 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 80012-47:
(7*8)+(6*0)+(5*0)+(4*1)+(3*2)+(2*4)+(1*7)=81
81 % 10 = 1
So 80012-47-1 is a valid CAS Registry Number.
InChI:InChI=1/C15H13N3O.BrH/c16-15-17-9-12-10-5-1-3-7-13(10)19-14-8-4-2-6-11(14)18(12)15;/h1-8,12H,9H2,(H2,16,17);1H
80012-47-1Relevant articles and documents
New tetracyclic guanidine derivatives with H1-antihistaminic properties. Chemistry of epinastine
Walther,Daniel,Bechtel,Brandt
, p. 440 - 446 (2007/10/02)
A series of new tetracyclic guanides were synthesized by various methods. Specific binding of the described compounds to histamine-1 and histamine-2 receptors was determined. The compound 3-amino-9, 13b-dihydro-1H-dibenz[c,f]imidazo[1,5-a]azepine (epinastine, WAL 801) combines high selectivity with high affinity for the H1 receptor and was selected from the compounds studied for further pharmacological and clinical investigations. Experimentally determined physicochemical parameters (pk(a)-value, partition coefficient) and the hydrogen-bonding ability of epinastine are indications that this compound will not easily cross the blood-brain barrier. This explains the absence of CNS side-effects of epinastine in pharmacological and clinical studies.