80015-54-9

Basic information

• Product Name: 9-[2-O-(4-methoxybenzyl)pentofuranosyl]-9H-purin-6-amine
• CAS NO: 80015-54-9
• Molecular Formula: C₁₈H₂₁N₅O₅
• Molecular Weight: 387.3898
• Mol File: 80015-54-9.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 702.1°C at 760 mmHg
• Flash Point: 378.4°C
• Density: 1.59g/cm³
• Vapor Pressure: 1.09E-20mmHg at 25°C
• Refractive Index: 1.72
• CAS DataBase Reference: 9-[2-O-(4-methoxybenzyl)pentofuranosyl]-9H-purin-6-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 9-[2-O-(4-methoxybenzyl)pentofuranosyl]-9H-purin-6-amine(80015-54-9)
• EPA Substance Registry System: 9-[2-O-(4-methoxybenzyl)pentofuranosyl]-9H-purin-6-amine(80015-54-9)

Safety Data

• Hazardous Substances Data: 80015-54-9(Hazardous Substances Data)

Upstream product

• 2746-25-0 p-Methoxybenzyl bromide 
• 58-61-7 adenosine 
• 824-94-2 p-methoxybenzyl chloride 
• 142031-35-4 adinosine 

Downstream Products

• 80015-58-3 N⁶-benzoyl-2'-O-(p-methoxybenzyl)adenosine 
• 58-61-7 adenosine 
• 80015-60-7 5'-O-dimethoxytrityl-2'-O-(4-methoxybenzyl)-N⁶-benzoyl adenosine 
• 4546-55-8 N-benzoyladenosine 

Relevant articles and documents

Structure-guided design of fluorescent S-adenosylmethionine analogs for a high-throughput screen to target SAM-I riboswitch RNAs

Many classes of S-adenosylmethionine (SAM)-binding RNAs and proteins are of interest as potential drug targets in diverse therapeutic areas, from infectious diseases to cancer. In the former case, the SAM-I riboswitch is an attractive target because this structured RNA element is found only in bacterial mRNAs and regulates multiple genes in several human pathogens. Here, we describe the synthesis of stable and fluorescent analogs of SAM in which the fluorophore is introduced through a functionalizable linker to the ribose. A Cy5-labeled SAM analog was shown to bind several SAM-I riboswitches via in-line probing and fluorescence polarization assays, including one from Staphylococcus aureus that controls the expression of SAM synthetase in this organism. A fluorescent ligand displacement assay was developed and validated for high-throughput screening of compounds to target the SAM-I riboswitch class.

CYCLIC DINUCLEOTIDES AS STING AGONISTS

Disclosed are compounds, compositions and methods for treating of diseases, syndromes, or disorders that are affected by the modulation of STING. Such compounds are represented by Formula (I), wherein R1, R1', X1, B1

COMPOSITIONS AND METHODS OF MODULATING THE IMMUNE RESPONSE BY ACTIVATING ALPHA PROTEIN KINASE 1

The disclosure provides compositions and methods related to activating alpha-kinase 1 (ALPK1) for modulating an immune response and treating or preventing cancer, infection, inflammation and related diseases and disorders as well as potentiating an immune response to a target antigen. The disclosure also provides heterocyclic compounds of formula (I) as agonists of alpha protein kinase 1 (ALPK1) and their use in activating ALPK1, modulating an immune response and treating diseases such as cancer, wherein A1, A2, L1, L2, L3, Z1, Z2, W1, W2, R1, R2, R3, R4, R5, R6 and R7 are defined herein.