80024-93-7Relevant articles and documents
AN EFFICIENT SYNTHESIS OF THE ENANTIOMERS OF METHADONE-d10
Gerardy, B. M.,Poupaert, J.,Dumont, P.
, p. 977 - 980 (2007/10/02)
A reactions sequence is described to prepare the enantiomers of Methadone-d10.The proposed scheme allows to synthesize racemic Methadone-d10 with 14percent overall yield, starting from benzene-d6. (-)-Methadone-d10 hydrochloride is assigned the (R)- absolute configuration on the basis of its ORD curve.