80086-21-1

Basic information

• Product Name: 2-Pentanone, 5-chloro-1-phenyl-
• CAS NO: 80086-21-1
• Molecular Formula: C11H13ClO
• Molecular Weight: 196.677
• Mol File: 80086-21-1.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: 2-Pentanone, 5-chloro-1-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Pentanone, 5-chloro-1-phenyl-(80086-21-1)
• EPA Substance Registry System: 2-Pentanone, 5-chloro-1-phenyl-(80086-21-1)

Safety Data

• Hazardous Substances Data: 80086-21-1(Hazardous Substances Data)

Upstream product

• 73013-83-9 1-benzyl-1-hydroxycyclobutane 
• 6921-34-2 benzylmagnesium chloride 
• 14267-92-6 1-chloro-4-pentyne 
• 6940-76-7 1-iodo-3-chloro-propane 
• 122-78-1 phenylacetaldehyde 
• 104311-88-8 2-bromo-5-chloro-1-phenylpentan-1-one 
• 28488-90-6 5-chloro-1-diazo-2-pentanone 
• 71-43-2 benzene 
• 104311-89-9 4,5-epoxy-5-phenyl-1-chloropentane 
• 100-39-0 benzyl bromide 
• 4635-59-0 4-Chlorobutanoyl chloride 

Downstream Products

• 80087-42-9 1-Methyl-5-(3-benzylcarbonylpropyl)thio-1,2,3,4-tetrazole 
• 133845-28-0 7a-Benzyl-hexahydro-pyrrolo[2,1-b]oxazole 
• 14113-94-1 2-phenyl-1-cyclopropylethan-1-one 
• 141809-38-3 5-[(2-Hydroxy-ethyl)-methyl-amino]-1-phenyl-pentan-2-one 

Relevant articles and documents

Manganese-Catalyzed Electrochemical Deconstructive Chlorination of Cycloalkanols via Alkoxy Radicals

A manganese-catalyzed electrochemical deconstructive chlorination of cycloalkanols has been developed. This electrochemical method provides access to alkoxy radicals from alcohols and exhibits a broad substrate scope, with various cyclopropanols and cyclobutanols converted into synthetically useful β- and γ-chlorinated ketones (40 examples). Furthermore, the combination of recirculating flow electrochemistry and continuous inline purification was employed to access products on a gram scale.

Regioselective Arene and Heteroarene Functionalization: N-Alkenoxypyridinium Salts as Electrophilic Alkylating Agents for the Synthesis of α-Aryl/α-Heteroaryl Ketones

A direct regioselective functionalization of arenes and heteroarenes using N-alkenoxypyridinium salts as electrophilic alkylating agents for the synthesis of α-aryl/heteroaryl ketones has been developed. The method generates alkylating agents from alkynes and N-pyridine oxide followed by site-selective electrophilic substitution with a broad range of arenes and heteroarenes including benzene derivates, phenols, ethers, indoles, pyrroles, furans, and thiophenes in one pot. Kinetic isotope effect measurements and DFT studies reveal that this reaction likely proceeds through a carbon-cation intermediate.

Benzylic Manganese Halides, Sulfonates, and Phosphates: Preparation, Coupling Reactions, and Applications in Organic Synthesis

The use of highly active manganese, prepared by the Rieke method, for the direct preparation of benzylic manganese reagents was investigated. The oxidative addition of the highly active manganese (Mn*) to benzylic halides was easily completed under mild conditions. More importantly, benzylic manganese sulfonates and phosphates were prepared by direct oxidative addition of Mn* to the carbon-oxygen bonds of benzylic sulfonates and phosphates. The resulting benzylic manganese reagents were found to undergo cross-coupling reactions with a variety of electrophiles. The majority of these reactions were carried out in the absence of any transition metal catalyst under mild conditions. This approach also provided a facile synthetic route to the preparation of resorcinolic lipids.