80096-54-4

Basic information

• Product Name: (2R)-2-amino-1-phenylpropan-1-one
• CAS NO: 80096-54-4
• Molecular Formula: C₉H₁₁NO
• Molecular Weight: 149.1897
• Mol File: 80096-54-4.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 255°C at 760 mmHg
• Flash Point: 108°C
• Density: 1.054g/cm³
• Vapor Pressure: 0.0167mmHg at 25°C
• Refractive Index: 1.54
• CAS DataBase Reference: (2R)-2-amino-1-phenylpropan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: (2R)-2-amino-1-phenylpropan-1-one(80096-54-4)
• EPA Substance Registry System: (2R)-2-amino-1-phenylpropan-1-one(80096-54-4)

Safety Data

• Hazardous Substances Data: 80096-54-4(Hazardous Substances Data)

Upstream product

• 5265-18-9 (+/-)-cathinone 
• 72739-14-1 (-)-Cathinone hydrochloride 
• 108832-95-7 tert-butyl N-(1-oxo-1-phenylpropan-2-(2R)-yl)carbamate 
• 37577-28-9 (1S,2R)-(+)-norphedrine 
• 579-07-7 1-Phenylpropane-1,2-dione 

Downstream Products

• 37577-28-9 (1S,2R)-(+)-norphedrine 

Relevant articles and documents

Evaluation of the Edman degradation product of vancomycin bonded to core-shell particles as a new HPLC chiral stationary phase

A modified macrocyclic glycopeptide-based chiral stationary phase (CSP), prepared via Edman degradation of vancomycin, was evaluated as a chiral selector for the first time. Its applicability was compared with other macrocyclic glycopeptide-based CSPs: TeicoShell and VancoShell. In addition, another modified macrocyclic glycopeptide-based CSP, NicoShell, was further examined. Initial evaluation was focused on the complementary behavior with these glycopeptides. A screening procedure was used based on previous work for the enantiomeric separation of 50 chiral compounds including amino acids, pesticides, stimulants, and a variety of pharmaceuticals. Fast and efficient chiral separations resulted by using superficially porous (core-shell) particle supports. Overall, the vancomycin Edman degradation product (EDP) resembled TeicoShell with high enantioselectivity for acidic compounds in the polar ionic mode. The simultaneous enantiomeric separation of 5 racemic profens using liquid chromatography-mass spectrometry with EDP was performed in approximately 3?minutes. Other highlights include simultaneous liquid chromatography separations of rac-amphetamine and rac-methamphetamine with VancoShell, rac-pseudoephedrine and rac-ephedrine with NicoShell, and rac-dichlorprop and rac-haloxyfop with TeicoShell.

Chiral separation of cathinone derivatives used as recreational drugs by HPLC-UV using a CHIRALPAK AS-H column as stationary phase

Cathinone derivatives gained high popularity on the recreational drugs market during the past 10 years. All these compounds are chiral, and the pharmacological potency of the enantiomers of these stimulants is supposed to differ. The goal of this research was to develop a reliable and easy-to-perform high-performance liquid chromatography ultraviolet method for the chiral separation of a set of 24 cathinone derivatives. A commercially available CHIRALPAK AS-H column consisting of amylose tris [(S)-α- methylbenzylcarbamate] coated on 5-μm silica gel was found to be suitable to resolve a majority of the tested compounds. High-performance liquid chromatography measurements were performed in normal phase mode under isocratic conditions with a mobile phase consisting of hexane, isopropanol, and triethylamine at a flowrate of 1 ml/min. The ratio between hexane and isopropanol was optimized by means of three model substances. Under final conditions with a mobile phase of hexane, isopropanol, and triethylamine (97:3:0.1), 19 out of 24 compounds were successfully resolved into their enantiomers and detected at a wavelength of 254 nm. A correlation between the substituents of the nitrogen atom and the separation results are shown. Furthermore, enantiomer separation results of four cathinone derivatives were compared with the results of their amphetamine analogs. Copyright

Enantiomeric α-aminopropiophenones (cathinone): Preparation and investigation

-