801315-74-2

Basic information

• Product Name: 1-Boc-4-aminoindazole
• Synonyms: 1-Boc-4-aminoindazole;1-BOC-1H-INDAZOL-4-AMINE;1H-INDAZOLE-1-CARBOXYLIC ACID,4-AMINO-,1,1-DIMETHYLETHYL ESTER-;tert-butyl 4-amino-1H-indazole-1-carboxylate;4-Amino-1H-indazole, N1-BOC protected;4-Amino-1H-indazole-1-carboxylic acid tert-butyl ester;4-Amino-indazole-1-carboxylic acid tert-butyl ester;1,1-Dimethylethyl 4-amino-1H-indazole-1-carboxylate
• CAS NO: 801315-74-2
• Molecular Formula: C₁₂H₁₅N₃O₂
• Molecular Weight: 233.27
• Product Categories: Building Blocks;Indazole
• Mol File: 801315-74-2.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 395.3°C at 760 mmHg
• Flash Point: 192.8°C
• Appearance: /
• Density: 1.24g/cm³
• Vapor Pressure: 1.86E-06mmHg at 25°C
• Refractive Index: 1.596
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 2.62±0.10(Predicted)
• CAS DataBase Reference: 1-Boc-4-aminoindazole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Boc-4-aminoindazole(801315-74-2)
• EPA Substance Registry System: 1-Boc-4-aminoindazole(801315-74-2)

Safety Data

• Hazardous Substances Data: 801315-74-2(Hazardous Substances Data)

Usage

General Description

1-Boc-4-aminoindazole is a chemical compound consisting of a 1-Boc (tert-butoxycarbonyl) group attached to a 4-aminoindazole molecule. It is a white to off-white solid that is mainly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. The 1-Boc group serves as a protective group for the amino group, allowing for selective manipulation of the molecule's reactivity. 1-Boc-4-aminoindazole has potential applications in the development of new drugs and bioactive compounds. It is important for its use as a precursor in organic synthesis and its potential pharmaceutical and agrochemical properties.

InChI:InChI=1/C12H15N3O2/c1-12(2,3)17-11(16)15-10-6-4-5-9(13)8(10)7-14-15/h4-7H,13H2,1-3H3

Upstream product

• 801315-75-3 tert-butyl 4-nitro-1H-indazole-1-carboxylate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 2942-40-7 nitro-4 indazole 
• 603-83-8 3-nitro-o-tolylamine 

Relevant articles and documents

EP300/CREBBP INHIBITOR

The present invention provides a compound having excellent histone acetyltransferase inhibitory activity against EP300 and/or CREBBP, or a pharmacologically acceptable salt thereof. The compound is represented by the following formula (1) or a pharmacologically acceptable salt thereof: wherein ring Q1, ring Q2, R1, R2, R3 and R4 respectively have the same meanings as defined in the specification.

Compound with dual inhibitory activity TDO, IDOO1 and application of compound for treating neurodegenerative disease (by machine translation)

The present invention provides a compound of formula I, or a pharmaceutically acceptable salt thereof, or a solvate thereof, which can selectively inhibit TDO, IDOO1, which has a significant inhibitory effect on TDO and/or IDOO1. In addition, the prepared compound has a remarkable anti-tumor effect, has a certain treatment effect on's disease and's disease, and has a good application prospect in the field of medicine preparation. (by machine translation)

Synthesis of novel N-Aryl-1H-indazolamines from amino-1H-indazoles and arylboronic acids

An efficient and high-yielding synthesis of N-aryl-1H-indazolamines from amino-1H-indazole and arylboronic acids are described. In this study a series of novel N-aryl-1H-indazolamines (1a-i) were synthesized using arylboronic acids and amino-1 H-indazoles