80173-35-9

Basic information

• Product Name: 5-(2-cyanovinyl)-2'-deoxyuridine
• Synonyms: 5-(2-cyanovinyl)-2'-deoxyuridine
• CAS NO: 80173-35-9
• Molecular Formula: C₁₂H₁₃N₃O₅
• Molecular Weight: 279.25
• Mol File: 80173-35-9.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• Density: 1.586±0.06 g/cm3(Predicted)
• PKA: 8.31±0.10(Predicted)
• CAS DataBase Reference: 5-(2-cyanovinyl)-2'-deoxyuridine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(2-cyanovinyl)-2'-deoxyuridine(80173-35-9)
• EPA Substance Registry System: 5-(2-cyanovinyl)-2'-deoxyuridine(80173-35-9)

Safety Data

• Hazardous Substances Data: 80173-35-9(Hazardous Substances Data)

Upstream product

• 16640-68-9 cyanomethylene triphenylphosphorane 
• 4494-26-2 5-formyl-2'-deoxyuridine 

Relevant articles and documents

Combining Wittig Olefination with Photoassisted Domino Reaction to Distinguish 5-Formylcytosine from 5-Formyluracil

In view of the important epigenetic functions of 5-formylcytosine (5fC), the development of quantitative detection methods for 5fC is a long-standing issue. In this regard, how to distinguish 5fC from 5-formyluracil to achieve higher accuracy is particularly difficult because the latter one is more reactive. Herein, we reported a phosphorus ylide, YC-CN, and introduced a triple domino reaction to fluorescently switch on 5fC with excellent selectivity, which also enable us to quantify 5fC mutations induced by γ-irradiation. This Wittig-initiated covalent labeling strategy provide a novel strategy for qualitative and quantitative detection of 5fC.