80213-12-3

Basic information

• Product Name: 4-Piperidinol, 1-[(4-methylphenyl)sulfonyl]-
• CAS NO: 80213-12-3
• Molecular Formula: C12H17NO3S
• Molecular Weight: 255.338
• Mol File: 80213-12-3.mol
• Article Data: 15

Chemical Properties

• CAS DataBase Reference: 4-Piperidinol, 1-[(4-methylphenyl)sulfonyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Piperidinol, 1-[(4-methylphenyl)sulfonyl]-(80213-12-3)
• EPA Substance Registry System: 4-Piperidinol, 1-[(4-methylphenyl)sulfonyl]-(80213-12-3)

Safety Data

• Hazardous Substances Data: 80213-12-3(Hazardous Substances Data)

Upstream product

• 5382-16-1 4-HYDROXYPIPERIDINE 
• 98-59-9 p-toluenesulfonyl chloride 
• 40064-34-4 piperidine-4,4-diol hydrochloride 
• 41979-39-9 4-piperidone hydrochloride 
• 4727-72-4 1-benzyl-4-hydroxypiperidine 
• 67-56-1 methanol 
• 201230-82-2 carbon monoxide 
• 289890-80-8 4-iodo-1-[(4-methylphenyl)sulfonyl]piperidine 
• 824-79-3 sodium 4-methylbenzenesulfinate 

Downstream Products

• 143632-57-9 N-(toluenesulfonyl)-4-phenylpiperidine 
• 928256-40-0 4-(4-methoxyphenyl)-1-tosylpiperidine 
• 57186-75-1 1-tosyl-1,2,5,6-tetrahydropyridine 
• 4703-22-4 N-tosylpiperidine 
• 101767-94-6 1-<(4-methylphenyl)sulfonyl>-4-piperidinol 4-methylbenzenesulfonate ester 
• 101294-01-3 4-methyl-N-(3-oxo-3-phenyl-propyl)benzenesulfonamide 
• 886198-30-7 4-(4-fluoro-phenyl)-1-(toluene-4-sulfonyl)-piperidine-3,4-diol 
• 886198-31-8 4-(4-chloro-phenyl)-1-(toluene-4-sulfonyl)-piperidine-3,4-diol 
• 886198-32-9 4-(4-methoxy-phenyl)-1-(toluene-4-sulfonyl)-piperidine-3,4-diol 
• 886198-33-0 4-(3-methoxy-phenyl)-1-(toluene-4-sulfonyl)-piperidine-3,4-diol 
• 93950-92-6 4-phenyl-1-(toluene-4-sulfonyl)-piperidine-3,4-diol 
• 886198-37-4 C₁₇H₁₆FNO₄S 
• 886198-39-6 C₁₈H₁₉NO₅S 
• 886198-40-9 C₁₈H₁₉NO₅S 

Relevant articles and documents

Nickel-Catalyzed Cyanation of Unactivated Alkyl Sulfonates with Zn(CN)2

Cyanation of unactivated primary and secondary alkyl mesylates with Zn(CN)2 catalyzed by nickel has been developed. The reaction provides an efficient route for the synthesis of alkyl nitriles with wide substrate scope, good functional group tolerance, and compatibility with heterocyclic compounds. Mechanistic studies indicate that alkyl iodide generated in situ serves as the reactive intermediate and the gradual release of alkyl iodide is crucial for the success of the reaction.

Copper-Catalyzed and Indium-Mediated Methoxycarbonylation of Unactivated Alkyl Iodides with Balloon CO

This work emphasizes the synthesis of alkyl esters via Cu-catalyzed and In-mediated alkoxycarbonylation of unactivated alkyl iodides in the presence of In or InI. The reactions were suitable for the preparation of primary, secondary, and even tertiary alkyl esters, representing an exceptionally rare example for the creation of quaternary carbon centers upon formation of esters. The preliminary mechanistic studies indicated that alkyl radicals were involved, and Cu/In/CO played a cooperative role in the carbonylation event.

PTAB mediated open air synthesis of sulfonamides, thiosulfonates and symmetrical disulfanes

A facile methodology has been described which has successfully simplified the generation of sulfonamides, thiosulfonates and symmetric disulfanes. This “trio” of reactions occur in an open air metal free atmosphere and has also been scaled up to grams making it suitable for commercialization. The reactions also have been successfully carried out with asymmetric variants, thus contributing to the chiral pool. The user friendly “trio” enables easy generation of these versatile sulfur analogues and the reaction condition employed depict an economic outline.