80217-67-0

Basic information

• Product Name: Ethanone, 1-[2-(2-propenylamino)phenyl]-
• CAS NO: 80217-67-0
• Molecular Formula: C11H13NO
• Molecular Weight: 175.23
• Mol File: 80217-67-0.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Ethanone, 1-[2-(2-propenylamino)phenyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 1-[2-(2-propenylamino)phenyl]-(80217-67-0)
• EPA Substance Registry System: Ethanone, 1-[2-(2-propenylamino)phenyl]-(80217-67-0)

Safety Data

• Hazardous Substances Data: 80217-67-0(Hazardous Substances Data)

Upstream product

• 613-89-8 2-Aminoacetophenone 
• 106-95-6 allyl bromide 
• 551-93-9 2-aminoacetophenone 

Downstream Products

• 830-74-0 1-allyl-1H-indole-2,3-dione 
• 1326778-55-5 (E)-1-(2-(allylamino)phenyl)ethanone oxime 
• 1010691-00-5 1-(2-(allylamino)phenyl)ethanone oxime 
• 583027-88-7 phosphoric acid 1-{2-[allyl-(toluene-4-sulfonyl)-amino]-phenyl}-vinyl ester diethyl ester 
• 583027-80-9 N-(2-acetylphenyl)-N-allyl-4-methylbenzenesulfonamide 

Relevant articles and documents

Synthesis, characterization and anticancer activity of novel ferrocene containing quinolinones: 1-Allyl-2-ferrocenyl-2,3-dihydroquinolin-4(1H)-ones and 1-allyl-2-ferrocenylquinolin-4(1H)-ones

A two new series of ferrocene containing quinolinones – 1-allyl-2-ferrocenyl-2,3-dihydroquinolin-4(1H)-ones and 1-allyl-2-ferrocenylquinolin-4(1H)-ones – were prepared and characterized by standard spectroscopic techniques and cyclic voltammetry. The in vitro antitumor activity of all synthesized compounds was investigated against Human Cervix Carcinoma (HeLa), Chronic Myelogenous Leukemia (K562) and normal endothelial (HUVEC) cell lines using the MTT method. Quinolone derivative 5c exhibited the highest cytotoxic activity in the cell growth inhibition of HeLa cell line while 5f was the most toxic against K562 cells.

Direct synthesis of 2-aryl-4-quinolones via transition-metal-free intramolecular oxidative C(sp3)-H/C(sp3)-H coupling

A novel, metal-free oxidative intramolecular Mannich reaction was developed between secondary amines and unmodified ketones, affording a simple and direct access to a broad range of 2-arylquinolin-4(1H)-ones through C(sp3)-H activation/C(sp3)-C(sp3) bond formation from readily available N-arylmethyl-2-aminophenylketones, using TEMPO as the oxidant and KOtBu as the base.

A practical, metal-free synthesis of 1H-Lndazoles

The synthesis of 1H-indazoles is achieved from o-aminobenzoximes by the selective activation of the oxime in the presence of the amino group. The reaction occurs with a variety of substituted o-aminobenzoximes using a slight excess of methanesulfonyl chloride and triethylamine at 0-23 °C and is amenable to scale-up. The synthesis of 1 H-indazoles under these conditions is extremely mild compared with previous synthetic approaches and affords the desired compounds in good to excellent yields.