80235-72-9

Basic information

• Product Name: 1-(3,4-dimethoxyphenyl)-2-(3,4,5-trimethoxyphenyl)ethan-1-one
• Synonyms: 1-(3,4-dimethoxyphenyl)-2-(3,4,5-trimethoxyphenyl)ethan-1-one
• CAS NO: 80235-72-9
• Molecular Weight: 346.38
• Mol File: 80235-72-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1-(3,4-dimethoxyphenyl)-2-(3,4,5-trimethoxyphenyl)ethan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3,4-dimethoxyphenyl)-2-(3,4,5-trimethoxyphenyl)ethan-1-one(80235-72-9)
• EPA Substance Registry System: 1-(3,4-dimethoxyphenyl)-2-(3,4,5-trimethoxyphenyl)ethan-1-one(80235-72-9)

Safety Data

• Hazardous Substances Data: 80235-72-9(Hazardous Substances Data)

Upstream product

• 91-16-7 1,2-dimethoxybenzene 
• 39053-78-6 3,4,5-trimethoxyphenylacetyl chloride 
• 13338-63-1 2-(3,4,5-trimethoxyphenyl)acetonitrile 
• 122775-35-3 3,4-Dimethoxyphenylboronic acid 
• 951-82-6 3,4,5-trimethoxyphenyl acetic acid 

Downstream Products

• 115802-56-7 trans-N-(2,2-diethoxyethyl)-3-(3,4-dimethoxyphenyl)-6,7,8-trimethoxy-1-methyl-1,2,3,4-tetrahydroisoquinoline 
• 108134-73-2 trans-3-(3,4-dimethoxyphenyl)-6,7,8-trimethoxy-1-methyl-1,2,3,4-tetrahydroisoquinoline 
• 80235-76-3 1-(3,4-dimethoxyphenyl)-2-(3,4,5-trimethoxyphenyl)ethylamine 
• 80235-74-1 N-(1-(3,4-dimethoxyphenyl)-2-(3,4,5-trimethoxyphenyl)ethyl)formamide 

Relevant articles and documents

Novel diaryl-2H-azirines: Antitumor hybrids for dual-targeting tubulin and DNA

Multiple-target drugs may achieve better therapeutic effect via different pathways than single-target ones, especially for complex diseases. Tubulin and DNA are well-characterized molecular targets for anti-cancer drug development. A novel class of diaryl substituted 2H-azirines were designed based on combination of pharmacophores from Combretastatin A-4 (CA-4) and aziridine-type alkylating agents, which are known tubulin polymerization inhibitor and DNA damaging agents, respectively. The antitumor activities of these compounds were evaluated in vitro and 6h showed the most potent activities against four cancer cell lines with IC50 values ranging from 0.16 to 1.40 μM. Further mechanistic studies revealed that 6h worked as a bifunctional agent targeting both tubulin and DNA. In the nude mice xenograft model, 6h significantly inhibited the tumor growth with low toxicity, demonstrating the promising potential for further developing novel cancer therapy with a unique mechanism.

IMPROVED PREPARATION OF 5-HYDROXYPROTOBERBERINE DERIVATIVES VIA 3-ARYLTETRAHYDROISOQUINOLINES

A regioselective synthetic pathway is reported to prepare 5-hydroxytetrahydroprotoberberines, starting from readily avaiable isoquinoline derivatives.Bromoacetaldehyde diethyl acetal is found to be an effective and convenient reagent for N-alkylation of t