80253-66-3

Basic information

• Product Name: cyanomethyl 4-chlorobenzoate
• Synonyms: cyanomethyl 4-chlorobenzoate
• CAS NO: 80253-66-3
• Molecular Weight: 195.605
• Mol File: 80253-66-3.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: cyanomethyl 4-chlorobenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: cyanomethyl 4-chlorobenzoate(80253-66-3)
• EPA Substance Registry System: cyanomethyl 4-chlorobenzoate(80253-66-3)

Safety Data

• Hazardous Substances Data: 80253-66-3(Hazardous Substances Data)

Upstream product

• 7399-68-0 2-(4-chlorophenyl)-4,5-dihydro-1,3-oxazole 
• 75-05-8 acetonitrile 
• 74-11-3 para-chlorobenzoic acid 
• 372-09-8 cyanoacetic acid 
• 107-14-2 chloroacetonitrile 

Downstream Products

• 80253-67-4 tetrazol-5-ylmethyl 4-chlorobenzoate 
• 934811-69-5 3'-O-[p-chlorobenzoyl]-5'-O-trityl-2'-deoxyadenosine 

Relevant articles and documents

Divergent Palladium-Catalyzed Tandem Reaction of Cyanomethyl Benzoates with Arylboronic Acids: Synthesis of Oxazoles and Isocoumarins

A palladium-catalyzed tandem reaction of cyanomethyl benzoates with arylboronic acids has been achieved. Substitution at the 2-position of cyanomethyl benzoates was found to be crucial for the selective synthesis of oxazoles and isocoumarins. Cyanomethyl

Fe(III)-catalyzed oxidative coupling of alkylnitriles with aromatic carboxylic acids: Facile access to cyanomethyl esters

The first oxidative coupling of alkylnitriles with aromatic carboxylic acids using di-tert-butyl peroxide (DTBP) as oxidant was achieved under the catalysis of ionic Fe(III) complexes bearing an imidazolinium cation. This protocol features nontoxic iron catalysis, direct α-C(sp3)–H bond oxidative esterification of alkylnitriles, non-prefunctionalized starting materials, and a broad substrate scope with outstanding steric hindrance tolerance, providing a novel, straightforward, and green approach toward cyanomethyl ester synthesis.