80336-89-6

Basic information

• Product Name: 2-bromoethyl (4-methoxyphenyl)acetate
• CAS NO: 80336-89-6
• Molecular Formula: C₁₁H₁₃BrO₃
• Molecular Weight: 273.1231
• Mol File: 80336-89-6.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 350.9°C at 760 mmHg
• Flash Point: 166°C
• Density: 1.393g/cm³
• Vapor Pressure: 4.27E-05mmHg at 25°C
• Refractive Index: 1.537
• CAS DataBase Reference: 2-bromoethyl (4-methoxyphenyl)acetate(CAS DataBase Reference)
• NIST Chemistry Reference: 2-bromoethyl (4-methoxyphenyl)acetate(80336-89-6)
• EPA Substance Registry System: 2-bromoethyl (4-methoxyphenyl)acetate(80336-89-6)

Safety Data

• Hazardous Substances Data: 80336-89-6(Hazardous Substances Data)

Upstream product

• 4366-28-3 2-bromomethyl-2-(4-methoxyphenyl)-1,3-dioxolane 
• 2632-13-5 2-Bromo-4'-methoxyacetophenone 

Relevant articles and documents

A Lewis Acid Catalyzed 1,2 Aryl Shift in α-Haloalkyl Aryl Acetals: A Convenient Route to α-Arylalkanoic Acids

A new method for the synthesis of α-arylalkanoic acids is given, based on Lewis acid promoted rearrangement of acetals of primary and secondary α-haloalkyl aryl ketones (halo = Br, Cl) in hydrocarbon solvents.The reaction is selective, providing the esters of α-arylalkanoic acids in almost quantitative yields.The ability of "soft and borderline" Lewis acids in activating the carbon-halogen bond is compared with that of silver salts.The reaction mechanism is discussed.The present synthesis has been applied to some α-arylpropionic acids well-known as antiinflammatory drugs.