80353-43-1

Basic information

• Product Name: 3-benzyl-2-phenyl-1,3-thiazolidin-4-one
• Synonyms: 3-Benzyl-2-phenyl-thiazolidin-4-one
• CAS NO: 80353-43-1
• Molecular Formula: C₁₆H₁₅NOS
• Molecular Weight: 269.3614
• Mol File: 80353-43-1.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 492.1°C at 760 mmHg
• Flash Point: 251.4°C
• Density: 1.234g/cm³
• Vapor Pressure: 7.9E-10mmHg at 25°C
• Refractive Index: 1.646
• CAS DataBase Reference: 3-benzyl-2-phenyl-1,3-thiazolidin-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-benzyl-2-phenyl-1,3-thiazolidin-4-one(80353-43-1)
• EPA Substance Registry System: 3-benzyl-2-phenyl-1,3-thiazolidin-4-one(80353-43-1)

Safety Data

• Hazardous Substances Data: 80353-43-1(Hazardous Substances Data)

Usage

General Description

3-benzyl-2-phenyl-1,3-thiazolidin-4-one is a chemical compound with the molecular formula C15H13NOS. It is known for its diverse biological activities and is used in the development of pharmaceuticals. 3-benzyl-2-phenyl-1,3-thiazolidin-4-one has been studied for its potential anti-inflammatory, antioxidant, and antitumor properties. It has also been investigated for its potential use in treating diabetes and insulin resistance. Additionally, 3-benzyl-2-phenyl-1,3-thiazolidin-4-one has shown potential for use in the treatment of neurodegenerative diseases such as Alzheimer's and Parkinson's. Its unique structure and versatile medicinal properties make it an interesting compound for further research and pharmaceutical development.

Upstream product

• 100-52-7 benzaldehyde 
• 68-11-1 mercaptoacetic acid 
• 100-46-9 benzylamine 
• 80353-48-6 N-Benzyl-2-[(benzylcarbamoyl-methylsulfanyl)-phenyl-methylsulfanyl]-acetamide 
• 780-25-6 N-benzylidene benzylamine 
• 622-79-7 benzyl azide 

Downstream Products

• 141727-37-9 3-Benzyl-5-fluoro-2-phenyl-thiazolidin-4-one 
• 141727-43-7 3-Benzyl-5-fluoro-1,1-dioxo-2-phenyl-1λ⁶-thiazolidin-4-one 
• 141727-48-2 (3S,4S)/(3R,4R)-1-benzyl-3-fluoro-4-phenylazetidin-2-one 
• 141727-48-2 (3R,4S)/(3S,4R)-1-benzyl-3-fluoro-4-phenylazetidin-2-one 

Relevant articles and documents

An unexpected formation of 2-aryl-3-benzyl-1,3-thiazolidin-4-ones

The reactions of L-valine, arenealdehydes, mercaptoacetic acid and DIPEA produce 2-aryl-3-benzyl-1,3-thiazolidin-4-ones with moderate yields (48-65%). Characterization of the 1,3-thiazolidin-4-ones was achieved by NMR and confirmed by X-ray crystallograph

Sonochemical Green Synthesis of Yttrium Oxide (Y2O3) Nanoparticles as a Novel Heterogeneous Catalyst for the Construction of Biologically Interesting 1,3-Thiazolidin-4-ones

Abstract: This paper describes a facile and green strategy for the synthesis of yttrium oxide nanoparticles (Y2O3 NPs) by a straightforward process using Liriope platyphylla rhizome extract as the reducing agent and yttrium nitrate hexahydrate as the sole precursor without other additives. The crystallinity, surface chemistry, morphology, elemental composition, and thermal properties of the synthesized NPs are thoroughly investigated. The synthesized NPs shows remarkable catalytic activity for the construction of biologically interesting 1,3-thiazolidin-4-ones. Graphical Abstract: [Figure not available: see fulltext.].

A facile and effective procedure for the synthesis of 4-thiazolidinone derivatives using Y(OTf)3 as catalyst

ABSTRACT: A one-pot three-component reaction for the synthesis of 4-thiazolidinone derivatives has been established by reacting readily available and inexpensive starting materials of amines, aldehydes and thioglycolic acid using Y(OTf)3 (5 mol%) as catalyst in tetrahydrofuran. This method is very efficient due to low catalyst loading and mild reaction conditions and provides an efficient and promising synthetic strategy for the construction of the thiazolidinone skeleton.