80354-46-7

Basic information

• Product Name: 2,4,5-trichlorophenyl (2-chloroethyl)carbamate
• CAS NO: 80354-46-7
• Molecular Formula: C₉H₇Cl₄NO₂
• Molecular Weight: 302.9694
• Mol File: 80354-46-7.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 378.7°C at 760 mmHg
• Flash Point: 182.8°C
• Density: 1.517g/cm³
• Vapor Pressure: 6.16E-06mmHg at 25°C
• Refractive Index: 1.568
• CAS DataBase Reference: 2,4,5-trichlorophenyl (2-chloroethyl)carbamate(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4,5-trichlorophenyl (2-chloroethyl)carbamate(80354-46-7)
• EPA Substance Registry System: 2,4,5-trichlorophenyl (2-chloroethyl)carbamate(80354-46-7)

Safety Data

• Hazardous Substances Data: 80354-46-7(Hazardous Substances Data)

Usage

Chemical structure

A synthetic chemical compound with a 2,4,5-trichlorophenyl group attached to a (2-chloroethyl)carbamate group.

Common uses

Antimicrobial agent in personal care products such as soaps, detergents, and body washes.

Mechanism of action

Inhibits the growth of bacteria on the skin, promoting hygiene and cleanliness.

Environmental impacts

Environmental contamination due to its persistence and bioaccumulation in water and soil.

Antibiotic resistance

Contributes to the development of antibiotic-resistant bacteria, posing a threat to public health.

Regulation status

Banned in some countries due to its potential health and environmental risks.

Need for further research

To better understand the long-term effects of triclocarban on human health and the environment, and to inform future regulations.

Upstream product

• 1943-83-5 2-chloroethyl isothiocyanate 
• 95-95-4 2,4,5-trichlorophenol 
• 16947-69-6 2,4,5-Trichlorophenyl chloroformate 
• 870-24-6 2-chloroethanamine hydrochloride 

Downstream Products

• 80354-51-4 N-(chloro-2 ethyl)N-nitrosocarbamate de trichloro-2,4,5 phenyle 

Relevant articles and documents

Synthesis and preliminary in vitro evaluation of antitumor nitrosoureido cholesterol derivatives

A new class of chloroethyl nitrosourea analogues of cholesterol has been synthetized from the corresponding 7-amino and 7-aminoalkylcholesterol derivatives. Compounds III-V inhibited L1210 cell growth in culture much more effectively than N,N'-bis(2-cgloroethyl)-N'-nitrosourea (BCNU) after 48 h incubation. Stability and cytotoxic activity of these prodrugs are promising for brain tumor treatments and as lymphotropic vectors for tumor cells spreading along the lymphatic pathways.

Activated N-Nitrosocarbamates for Regioselective Synthesis of N-Nitrosoureas

A practical and convenient method for synthesizing antitumor compounds, N-alkyl-N-nitrosoureas, regioselectively nitrosated on the nitrogen atom bearing the alkyl group is proposed.N-Alkyl-N-nitrosocarbamates are interesting intermediates in these syntheses and yield, by reaction with amino compounds, the regioselectively nitrosated N-alkyl-N-nitrosoureas.As an interesting example, N,N'-biscystamine, a new attractive oncostatic derivative, has been prepared.The cytotoxic activity of these various compounds were tested on L1210 leukemia.