80360-09-4

Basic information

• Product Name: 5-deazaaminopterin
• Synonyms: 5-deazaaminopterin;N-[4-[[(2,4-Diaminopyrido[2,3-d]pyrimidin-6-yl)methyl]amino]benzoyl]-L-glutamic acid
• CAS NO: 80360-09-4
• Molecular Formula: C₂₀H₂₁N₇O₅
• Molecular Weight: 439.42
• Mol File: 80360-09-4.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• Density: 1.547g/cm³
• Refractive Index: 1.754
• CAS DataBase Reference: 5-deazaaminopterin(CAS DataBase Reference)
• NIST Chemistry Reference: 5-deazaaminopterin(80360-09-4)
• EPA Substance Registry System: 5-deazaaminopterin(80360-09-4)

Safety Data

• Hazardous Substances Data: 80360-09-4(Hazardous Substances Data)

Usage

InChI:InChI=1/C20H21N7O5/c21-16-13-7-10(9-24-17(13)27-20(22)26-16)8-23-12-3-1-11(2-4-12)18(30)25-14(19(31)32)5-6-15(28)29/h1-4,7,9,14,23H,5-6,8H2,(H,25,30)(H,28,29)(H,31,32)(H4,21,22,24,26,27)

Upstream product

• 87373-68-0 (S)-2-{4-[(2,4-Diamino-pyrido[2,3-d]pyrimidin-6-ylmethyl)-amino]-benzoylamino}-pentanedioic acid dimethyl ester 
• 80360-08-3 N-<4-<<(2,4-diaminopyrido<2,3-d>pyrimidin-6-yl)methyl>amino>benzoyl>-L-glutamic acid diethyl ester 
• 13726-52-8 diethyl N-(p-aminobenzoyl)-L-glutamate 
• 101810-72-4 2,4-diaminopyrido<2,3-d>pyrimidine-6-carbonitrile 
• 87171-09-3 2,4-Diamino-6-(hydroxymethyl)pyrido[2,3-d]pyrimidine 
• 101348-11-2 6-(bromomethyl)-2,4-diaminopyrido[2,3-d]pyrimidine 
• 101348-09-8 6-(hydroxymethyl)pyrido<2,3-d>pyrimidine-2,4(1H,3H)-dione 
• 101348-01-0 5-cyano-1,3-bis(methoxymethyl)uracil 
• 101348-10-1 6-(acetoxymethyl)pyrido<2,3-d>pyrimidine-2,4(1H,3H)-dione 
• 101348-05-4 6-cyano-1,3-bis(methoxymethyl)pyrido<2,3-d>pyrimidine-2,4(1H,3H)-dione 
• 101348-04-3 7-chloro-6-cyano-1,3-bis(methoxymethyl)pyrido<2,3-d>pyrimidine-2,4(1H,3H)-dione 
• 101348-03-2 7-Hydroxy-1,3-bis-methoxymethyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrido[2,3-d]pyrimidine-6-carbonitrile 
• 101348-02-1 7-amino-6-cyano-1,3-bis(methoxymethyl)pyrido<2,3-d>pyrimidine-2,4(1H,3H)-dione 
• 101348-08-7 6-(acetoxymethyl)-1,3-bis(methoxymethyl)pyrido<2,3-d>pyrimidine-2,4(1H,3H)-dione 

Downstream Products

• 80360-10-7 N-[4-[[(2,4-Diaminopyrido[2,3-d]pyrimidine-6-yl)methyl]methylamino]benzoyl]-L-glutamic acid 
• 80360-12-9 5-deaza-10-methylfolic acid 
• 80360-06-1 2-amino-4(3H)-oxopyrido<2,3-d>pyrimidine-6-carboxylic acid 

Relevant articles and documents

New pathways from pteridines. Design and synthesis of a new class of potent and selective antitumor agents

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Syntheses and Antifolate Activity of 5-Methyl-5-deaza Analogues of Aminopterin, Methotrexate, Folic Acid, and N10-Methylfolic Acid

Evidence indicating that modifications at the 5- and 10-positions of classical folic acid antimetabolites lead to compounds with favorable differential membrane transport in tumor vs. normal proliferative tissue prompted an investigation of 5-alkyl-5-deaz

Pyrido[2,3-d]-pyrimidines

There is disclosed a novel intermediate useful in the preparation of pyrido[2,3-d]pyrimidines, which includes N-[4- [(2-amino-4(3H)-oxopyrido[2,3-d]pyrimidin-6-yl)methylamino]benzoyl]-L-glutamic acid (5-deazafolic acid), N-[4-[[(2-amino-4(3H)-oxopyrido[2,3-d]-pyrimidin-6-yl)methyl]methylamino]benzoyl]-L-glutamic acid (5-deaza-N10 -methylfolic acid), N-[4-[(2,4-diaminopyrido[2,3-d]pyrimidin-6-yl)methylamino]benzoyl]-L-glutamic acid (5-deazaaminopterin), and N-[4-[[(2,4-diaminopyrido[2,3-d]pyrimidin-6-yl)methyl]methylamino]benzoyl]-L-glutamic acid (5-deazamethotrexate). This intermediate is the compound 2,4-diaminopyrido[2,3-d]pyrimidine-6-carboxaldehyde.