80418-11-7

Basic information

• Product Name: (R)-2,2,2-trifluoro-1-(4'-chlorophenyl)ethanol
• Synonyms: (R)-2,2,2-trifluoro-1-(4'-chlorophenyl)ethanol
• CAS NO: 80418-11-7
• Molecular Weight: 210.583
• Mol File: 80418-11-7.mol
• Article Data: 43

Chemical Properties

• CAS DataBase Reference: (R)-2,2,2-trifluoro-1-(4'-chlorophenyl)ethanol(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-2,2,2-trifluoro-1-(4'-chlorophenyl)ethanol(80418-11-7)
• EPA Substance Registry System: (R)-2,2,2-trifluoro-1-(4'-chlorophenyl)ethanol(80418-11-7)

Safety Data

• Hazardous Substances Data: 80418-11-7(Hazardous Substances Data)

Upstream product

• 104-88-1 4-chlorobenzaldehyde 
• 81290-20-2 (trifluoromethyl)trimethylsilane 
• 321-37-9 4'-chloro-2,2,2-trifluoroacetophenone 
• 557-20-0 diethylzinc 
• 72487-06-0 1-(4-chlorophenyl)-2,2,2-trifluoroethanol 
• 97-72-3 2-Methylpropionic anhydride 
• 108-05-4 vinyl acetate 
• 421-53-4 2,2,2-trifluoro-1,1-ethanediol 
• 2923-18-4 sodium 2,2,2-trifluoroacetate 
• 2314-97-8 iodotrifluoromethane 
• 75-46-7 trifluoromethan 
• 106-39-8 bromochlorobenzene 
• 76-05-1 trifluoroacetic acid 
• 75-63-8 Bromotrifluoromethane 

Downstream Products

• 72487-06-0 (S)-1-(4-chlorophenyl)-2,2,2-trifluoroethan-1-ol 
• 1135311-91-9 (S)-2,2,2-trifluoro-1-(4'-chlorophenyl)ethyl isobutyrate 
• 1135312-26-3 2,2,2-trifluoro-1-(4'-chlorophenyl)ethyl isobutyrate 
• 1422984-88-0 2-(4-chlorophenyl)-1,1,1-trifluoro-3-nitropropan-2-ol 
• 1202576-95-1 1-(4-chlorophenyl)-2,2,2-trifluoroethyl trifluoromethanesulfonate 
• 321-37-9 4'-chloro-2,2,2-trifluoroacetophenone 
• 1996-64-1 2.2.2-Trifluor-1-phenyl-1-(4-chlor-phenyl)-aethan 
• 1422985-26-9 3-(2-(4-chlorophenyl)-1,1,1-trifluoro-3-nitropropan-2-yl)-1H-indole 

Relevant articles and documents

Highly enantioselective construction of CF3-bearing all-carbon quaternary stereocenters: Hiral spiro-fused bisoxazoline ligands with 1,1′-binaphthyl sidearm for asymmetric Michael-type Friedel-Crafts reaction

A novel class of chiral spiro-fused bisoxazoline ligands possessing a deep chiral pocket was prepared. The developed ligands have been employed in the nickel-catalyzed highly enantioselective Michael-type Friedel-Crafts reaction, affording the products bearing a trifluoromethylated all-carbon quaternary stereocenter with moderate to excellent yields (up to 99%) and good to excellent enantioselectivies (up to > 99.9% ee). Moreover, a proposed model of chiral pocket revealed that the attack of indole from the Re-face of β-CF3-β-disubstituted nitroalkene was favorable.

Asymmetric Hydrogenation of Aryl Perfluoroalkyl Ketones Catalyzed by Rhodium(III) Monohydride Complexes Bearing Josiphos Ligands

The asymmetric hydrogenation of 2,2,2-trifluoroacetophenones and aryl perfluoroalkyl ketones was developed using a unique, well-defined chloride-bridged dinuclear rhodium(III) complex bearing Josiphos-type diphosphine ligands. These complexes were prepared from [RhCl(cod)]2, Josiphos ligands, and hydrochloric acid. As catalyst precursors, they allow for the efficient and enantioselective synthesis (up to 99 % ee) of chiral secondary alcohols with perfluoroalkyl groups. This system does not require an activating base for the hydrogenation of 2,2,2-trifluoroacetophenones. Additionally, the enantioselective C=O hydrogenations of 2-phenyl-3-(haloacetyl)-indoles, a class of privileged structures in medicinal chemistry, is reported for the first time.

A method of manufacturing a trifluoromethyl group-containing compound

PROBLEM TO BE SOLVED: To provide a method for producing a trifluoromethyl group-containing compound useful as a synthetic intermediate for a pharmaceutical or an agricultural chemical product.SOLUTION: There is provided a method for producing a trifluoromethyl group-containing compound represented by the following general formula (2) which is obtained by reacting a carbonyl compound having a specific structure with trifluoromethane and an organic base in an organic solvent (wherein, Rrepresents a methyl group, an ethyl group, a linear, branched or cyclic alkyl group having 3 to 10 carbon atoms, a phenyl group, a substituted phenyl group, a naphthyl group, a substituted naphthyl group, an ethenyl group, a 2-phenylethenyl group, a 9-anthryl group or a hetero ring; Rrepresents a hydrogen atom, a methyl group or a phenyl group.)