80443-10-3

Basic information

• Product Name: 5-hydroxy-4'-methoxyflavone 7-O-β-D-galactopyranoside tetraacetate
• Synonyms: 5-hydroxy-4'-methoxyflavone 7-O-β-D-galactopyranoside tetraacetate
• CAS NO: 80443-10-3
• Molecular Weight: 614.56
• Mol File: 80443-10-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 5-hydroxy-4'-methoxyflavone 7-O-β-D-galactopyranoside tetraacetate(CAS DataBase Reference)
• NIST Chemistry Reference: 5-hydroxy-4'-methoxyflavone 7-O-β-D-galactopyranoside tetraacetate(80443-10-3)
• EPA Substance Registry System: 5-hydroxy-4'-methoxyflavone 7-O-β-D-galactopyranoside tetraacetate(80443-10-3)

Safety Data

• Hazardous Substances Data: 80443-10-3(Hazardous Substances Data)

Upstream product

• 10236-47-2 naringin 
• 4163-60-4 β-D-galactose peracetate 
• 99-96-7 4-hydroxy-benzoic acid 
• 100-09-4 4-methoxybenzoic acid 
• 100-07-2 4-methoxy-benzoyl chloride 
• 439-03-2 2,3,4,6-tetra-O-acetyl-α-D-galactopyranosyl fluoride 
• 480-44-4 5,7-dihydroxy-2-(4'-methoxyphenyl)-4H-1-benzopyran-4-one 
• 126641-47-2 C₁₄H₁₉FO₉ 
• 59115-98-9 2',4',6'-tri(p-methoxybenzoyloxy)acetophenone 
• 80443-16-9 C₃₂H₂₆O₁₀ 
• 480-66-0 2,4,6-trihydroxyacetophenone 
• 108-73-6 3,5-dihydroxyphenol 

Downstream Products

• 480-44-4 5,7-dihydroxy-2-(4'-methoxyphenyl)-4H-1-benzopyran-4-one 
• 80443-15-8 acacetin 7-O-β-D-galactopyranoside 

Relevant articles and documents

Semisynthesis of apigenin and acacetin-7-O-β-d-glycosides from naringin and their cytotoxic activities

Apigenin-7-O-β-d-glycosides 1-8 and acacetin-7-O-β-d-glycosides 9-16 were semisynthesized from 4′-O-benzyl apigenin 17 and acacetin 18 by glycosidation and deprotection with the corresponding α-acetylglycosyl bromide, respectively. Compounds 17 and 18 were prepared by iodination followed by base-induced elimination, 4′-O-benzylation, or 4′-O-methylation and acid hydrolysis using naringin as starting material which is readily available and cheap. Their cytotoxic potential against five human cancer cell lines (HL-60, SMMC-7721, A-549, MCF-7, and SW480) was evaluated by standard MTT method. The results show that compounds 2, 9, and 19 exhibit moderate cytotoxicity against HL-60, SMMC-7721, A-549, MCF-7, and SW480, while compound 3 exhibits potent cytotoxicity against MCF-7 selectively. Among the synthesized target compounds, 3, 4, 7, 11, 12, 15, and 16 were new compounds, the natural product 8 was the first synthesized and the synthesis of natural products 5, 6, 13, and 14 was efficiently improved by the new synthetic routes.

ACACETIN 7-O-β-D-GALACTOPYRANOSIDE FROM CHRYSANTHEMUM INDICUM

Key Word Index - Chrysanthemum indicum; Compositae; acacetin 7-O-β-D-galactopyranoside. From the yellow flowers of Chrysanthemum indicum, a new flavone glycoside, acacetin 7-O-β-D-galactopyranoside was isolated and its structure established from spectral evidence and synthesis.