80446-61-3

Basic information

• Product Name: (R)-α,3-bis(trifluoromethyl)-benzenemethanol
• CAS NO: 80446-61-3
• Molecular Weight: 244.136
• Mol File: 80446-61-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (R)-α,3-bis(trifluoromethyl)-benzenemethanol(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-α,3-bis(trifluoromethyl)-benzenemethanol(80446-61-3)
• EPA Substance Registry System: (R)-α,3-bis(trifluoromethyl)-benzenemethanol(80446-61-3)

Safety Data

• Hazardous Substances Data: 80446-61-3(Hazardous Substances Data)

Upstream product

• 721-37-9 2,2,2-trifluoro-3'-(trifluoromethyl)acetophenone 

Relevant articles and documents

Rational electronic tuning of CBS catalyst for highly enantioselective borane reduction of trifluoroacetophenone

α,α,α-Trifluoroacetophenone (2), which is susceptible to noncatalytic reduction by BH3, could be reduced to chiral alcohol up to 90% ee by using electronically tuned-CBS catalyst (1) with BH3. The enantioselectivities highly correlated with the differential orbital energies between 1-BH3 adduct and 2, which were calculated by DFT method.

Reduction by a Model of NAD(P)H. 34. Substituent Effect on Asymmetric Reduction of Trifluoroacetophenones

Substituted and unsubstituted α,α,α-trifluoroacetophenones were reduced by a chiral NAD(P)H-model (R,R-Me2PNPH).Both electron-releasing and -withdrawing substituents give better optical yields than unsubstituted compound.The result has been interpreted in