80483-89-2Relevant articles and documents
Toxicity of (22R,23R)-22,23-dihydroxystigmastane derivatives to cultured cancer cells
Misharin, Alexander Yu.,Mehtiev, Arif R.,Zhabinskii, Vladimir N.,Khripach, Vladimir A.,Timofeev, Vladimir P.,Tkachev, Yaroslav V.
, p. 287 - 294 (2010)
Toxicity of eight 22,23-dihydroxystigmastane derivatives (four pairs of (22R,23R)- and (22S,23S)-isomers differing in steroid backbone structure) to human breast carcinoma MCF-7 cells was compared. For every pair of structurally related compounds, (22R,23
SYNTHESIS OF 22S,23S-BRASSINOSTEROIDS BASED ON STIGMASTEROL
Akhrem, A. A.,Lakhvich, F. A.,Khripach, V. A.,Kovganko, N. V.,Zhabinskii, V. N.
, p. 686 - 692 (2007/10/02)
The analogs of 29C-brassinosteroids based on stigmasterol , i.e., 22S,23S-homocastasterone and 22S,23S-homobrassinolide, were synthesized.Electrophilic additions at the Δ22-bond, hydroxylation with osmium tetroxide, and epoxidation followed by conversion of the epoxide into the diol were used for the construction of the 22S,23S-diol grouping.
SYNTHESIS OF (22S,23S)-HOMOBRASSINOLIDE AND BRASSINOLIDE FROM STIGMASTEROL
Mori, Kenji,Sakakibara, Masayuki,Ichikawa, Yoshitaka,Ueda, Hiraki,Okada, Katsuhide,et al.
, p. 2099 - 2110 (2007/10/02)
(22S, 23S)-Homobrassinolide (2α, 3α, 22S, 23S-tetrahydroxy-24S-ethyl-B-homo-7-oxa-5α-cholestan-6-one) and brassinolide (2α, 3α, 22R, 23R-tetrahydroxy-24S-methyl-B-homo-7-oxa-5α-cholestan-6-one) were synthesized from stigmasterol and shown to promote plant growth.