805236-73-1

Basic information

• Product Name: Benzoic acid (2R,3S,5R)-3-{2-[9-((2R,4S,5R)-4-acetoxy-5-acetoxymethyl-tetrahydro-furan-2-yl)-9H-purin-6-ylamino]-prop-2-ene-1-sulfonyl}-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester
• Synonyms: Benzoic acid (2R,3S,5R)-3-{2-[9-((2R,4S,5R)-4-acetoxy-5-acetoxymethyl-tetrahydro-furan-2-yl)-9H-purin-6-ylamino]-prop-2-ene-1-sulfonyl}-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester
• CAS NO: 805236-73-1
• Molecular Weight: 767.773
• Mol File: 805236-73-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Benzoic acid (2R,3S,5R)-3-{2-[9-((2R,4S,5R)-4-acetoxy-5-acetoxymethyl-tetrahydro-furan-2-yl)-9H-purin-6-ylamino]-prop-2-ene-1-sulfonyl}-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid (2R,3S,5R)-3-{2-[9-((2R,4S,5R)-4-acetoxy-5-acetoxymethyl-tetrahydro-furan-2-yl)-9H-purin-6-ylamino]-prop-2-ene-1-sulfonyl}-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester(805236-73-1)
• EPA Substance Registry System: Benzoic acid (2R,3S,5R)-3-{2-[9-((2R,4S,5R)-4-acetoxy-5-acetoxymethyl-tetrahydro-furan-2-yl)-9H-purin-6-ylamino]-prop-2-ene-1-sulfonyl}-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester(805236-73-1)

Safety Data

• Hazardous Substances Data: 805236-73-1(Hazardous Substances Data)

Upstream product

• 805236-60-6 3'-(S)-(propargylthio)-5'-O-trityl-3'-deoxythymidine 
• 164231-21-4 1-((2R,4S,5R)-4-Mercapto-5-trityloxymethyl-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione 
• 805236-62-8 Benzoic acid (2R,3S,5R)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3-prop-2-ynylsulfanyl-tetrahydro-furan-2-ylmethyl ester 
• 805236-61-7 3'-deoxy-3'-(S)-(propargylthio)thymidine 
• 805236-59-3 5'-O-trityl-3'-(acetylthio)-2',3'-dideoxythymidine 
• 104218-44-2 1-(2-deoxy-3-O-methanesulfonyl-5-O-trityl-β-D-threo-pentofuranosyl)thymine 
• 17318-24-0 3',5'-di-O-acetyl-2'-deoxyadenosine 
• 805236-64-0 3'-(S)-(allenic sulfonyl)-5'-benzoyl-3'-deoxythymidine 

Relevant articles and documents

Synthesis and reactions of allenic sulfone-modified thymidine: The first allenic sulfone to alkylate deoxyadenosine

3′-(S)-(allenic sulfonyl)-5?-benzoyl-3?-deoxythymidine has been synthesized from 1-(5-O-trityl-3-O-mesyl-2-deoxy-β-D- threopentofuranosyl) thymine via 3′-(S)-(propargylthio)-5′-trityl- 3′-deoxythymidine in six steps. 3′-(S)-(allenic sulfonyl)-3′- deoxythymidine reacts very efficiently with a wide array of nucleophiles. This is also the first report on the alkylation of adenine moiety by some allenic sulfone modified compounds.