8053-00-7

Basic information

• Product Name: EINECS 200-278-5
• Synonyms: EINECS 200-278-5
• CAS NO: 8053-00-7
• Molecular Formula: C18H20O2
• Molecular Weight: 268.3502
• Mol File: 8053-00-7.mol
• Article Data: 12

Chemical Properties

• Appearance: /
• CAS DataBase Reference: EINECS 200-278-5(CAS DataBase Reference)
• NIST Chemistry Reference: EINECS 200-278-5(8053-00-7)
• EPA Substance Registry System: EINECS 200-278-5(8053-00-7)

Safety Data

• Hazardous Substances Data: 8053-00-7(Hazardous Substances Data)

Upstream product

• 7773-34-4 diethylstilbestrol dimethyl ether 
• 752225-73-3 C₂₀H₂₄O₂ 
• 120-44-5 1,4-di(4-methoxyphenyl)ethanone 
• 4390-94-7 1,2-bis(4-methoxyphenyl)butanone 
• 4646-94-0 2-(4-methoxyphenyl)-n-butanoic acid 
• 121-97-1 4-Methoxypropiophenone 
• 70-70-2 4-hydroxypropiophenone 
• 10467-10-4 ethylmagnesium iodide 
• 70244-10-9 4.4'-diethoxy-α.α'-diethyl-trans-stilbene 
• 130-79-0 Diethylstilbestrol dimethyl ether 
• 917-64-6 methyl magnesium iodide 
• 64-17-5 ethanol 
• 22610-99-7 cis-3,4-Bis(p-hydroxyphenyl)-3-hexene 
• 536-44-7 4-(1-bromo-propyl)-anisole 

Downstream Products

• 78993-06-3 4.4'-dioctanoyloxy-α.α'-diethyl-trans-stilbene 
• 119853-16-6 3,4-bis-[4-(2-benzyl-3-phenyl-propionyloxy)-phenyl]-hex-3t-ene 
• 109263-77-6 MDL₅₃₃₂ 
• 66877-36-9 3,4-bis-(4-hydroxy-3-nitro-phenyl)-hex-3t-ene 
• 101606-38-6 optically inactive 2,5-dichloro-3,4-bis-(3,5-dibromo-4-hydroxy-phenyl)-hex-3t-ene 
• 107522-91-8 optically inactive 2,5-dibromo-3,4-bis-(3,5-dibromo-4-hydroxy-phenyl)-hex-3t-ene 
• 17046-61-6 4.4'-disulfooxy-α.α'-diethyl-trans-stilbene; dipotassium-salt 
• 101942-05-6 4.4'-bis-ethoxycarbonyloxy-α.α'-diethyl-cis-stilbene 
• 101942-05-6 4.4'-bis-ethoxycarbonyloxy-α.α'-diethyl-trans-stilbene 
• 5965-06-0 trans-<4,4'-(diethylvinylen) bis (phenyl)>diacetate 
• 19943-38-5 4.4'-dibutyryloxy-α.α'-diethyl-trans-stilbene 
• 122802-50-0 3,4-bis-[4-(3-chloro-propionyloxy)-phenyl]-hex-3t-ene 
• 97573-41-6 3,3'-dicyclohexyl-3,4,3',4'-tetrahydro-2H,2'H-6,6'-((E)-1,2-diethyl-ethene-1,2-diyl)-bis-benzo[e][1,3]oxazine 
• 96711-51-2 3,3'-dibenzyl-3,4,3',4'-tetrahydro-2H,2'H-6,6'-((E)-1,2-diethyl-ethene-1,2-diyl)-bis-benzo[e][1,3]oxazine 

Relevant articles and documents

Diethylstilbestrol-scaffold-based pregnane X receptor modulators

Due to its function as a regulator of drug-metabolizing enzymes and transporters, pregnane X receptor (PXR) represents an important factor involved in drug metabolism. In this work, we describe the discovery of diethylstilbestrol-based PXR modulators, which were designed from marine sulfated steroids with PXR agonistic activity, solomonsterols A and B, and our recently reported bazedoxifene scaffold-derived PXR antagonists. The methylated diethylstilbestrol derivative 1 displayed potent PXR agonistic activity with an EC50 value of 10.5 μM, whereas compounds 3, 4 and 6 (IC50 for 6 = 27.4 μM) and diethylstilbestrol (2) itself (IC50 = 14.6 μM) exhibited PXR antagonistic effects in HepG2 cells. The PXR modulatory effects of the synthesized diethylstilbestrol derivatives were further confirmed by the induction of PXR-regulated CYP3A4 expression with compound 1, as well as by the inhibition of the rifaximin-promoted up-regulation of CYP3A4 expression with 2 and its derivative 6.

THERAPEUTIC FOR HEPATIC CANCER

A novel pharmaceutical composition for treating or preventing hepatocellular carcinoma and a method of treatment are provided. A pharmaceutical composition for treating or preventing liver cancer is obtained by combining a chemotherapeutic agent with an anti-glypican 3 antibody. Also disclosed is a pharmaceutical composition for treating or preventing liver cancer which comprises as an active ingredient an anti-glypican 3 antibody for use in combination with a chemotherapeutic agent, or which comprises as an active ingredient a chemotherapeutic agent for use in combination with an anti-glypican 3 antibody. Using the chemotherapeutic agent and the anti-glypican 3 antibody in combination yields better therapeutic effects than using the chemotherapeutic agent alone, and mitigates side effects that arise from liver cancer treatment with the chemotherapeutic agent.

Selectivity control by chemical modification of the recognition sites in two-point binding molecularly imprinted polymer

We demonstrated the possibility of modifying the selectivity of a two-point binding imprinted polymer by chemical modification of the binding sites inside the cavities. We used a thermally reversible bond for the preparation of the monomer-template complex, which allowed us to remove the template easily by means of a simple thermal reaction and to simultaneously introduce various functional groups into the cavity. A phenylmaleimide having an azidocarbonyl group was reacted with diethylstilbestrol (DES, template) to yield a monomer, where the template was linked to two polymerizable maleimido groups via a thermally reversible urethane bond. The polymerization of the monomer was carried out in the presence of ethylene glycol dimethacrylate (EGDMA) by the initiation with 2,2-azobis(isobutyronitrile) (AIBN) at 54°C in DMF. The polymers were refluxed in 1,4-dioxane in the presence of a nucleophile such as water, methanol, or aniline. In this extraction step, the template molecules were removed from the polymer matrix, and simultaneously the isocyanato groups, which were generated by the thermal cleavage of the urethane bond, were converted to amino, urethane, or urea groups through their reaction with water, methanol, or aniline, respectively. The specific recognition ability of the imprinted polymers for the template and its structural analogues was dependent on the space between the two binding points as well as on the nature of the functional group. This method is especially propitious for developing artificial receptors for molecules lacking strongly interactive groups.