80536-46-5Relevant articles and documents
A convenient procedure for transformation of tertiary cyclopropanols into 5-substituted isoxazoles
Churykau, Dzmitry H.,Kulinkovich, Oleg G.
, p. 3427 - 3430 (2007/10/03)
Tertiary cyclopropanols, when treated with an excess of amyl nitrite at room temperature, are smoothly converted into dimeric β-nitrosoketones. Heating the methanolic solutions of the latter under reflux gives 5-substituted isoxazoles in good yields. Geor
ISOXAZOLES AS 4b-DIKETONE SYNTHONS-SELECTIVE ANION FORMATION ON 3,5-DIALKYLISOXAZOLES
Brunelle, D. J.
, p. 3699 - 3702 (2007/10/02)
3,5-Dimethylisoxazole can be metalated and alkylated regiospecifically.Alkylation occurs first on the 5-methyl group, and a second alkylation occurs on the 3-methyl group.This method permits specific synthesis of disubstituted isoxazoles, and of the corresponding β-diketones.