80540-68-7Relevant articles and documents
Discovery of novel dihydroartemisinin-cinnamic hybrids inducing lung cancer cells apoptosis via inhibition of Akt/Bad signal pathway
Hu, Yanping,Wang, Yujin,Li, Na,Chen, Li,Sun, Jianbo
, (2021/04/27)
A series of dihydroartemisinin-cinnamic acid hybrids were designed, synthesized and evaluated. Most of the tested compounds showed enhanced anti-proliferative activities than artemisinin and dihydroartemisinin, among which 16 g had the superior potency with IC50 values ranging from 5.07 μM to 7.88 μM against four tested cancer cell lines. The cell cycle arrest revealed that 16 g induced A549 cell cycle arrest at G0/G1 phase via regulation of G1-related protein expression (Cdk4). Further mechanism studies reveal that 16 g induced A549 cells apoptosis via inhibiting Akt/Bad pathway. Moreover, 16 g depolarized the mitochondria membrane potentials and induced ROS generation in A549. Additionally, 16 g blocked migration of A549 cells in a concentration-dependent manner. What's more, 16 g is barely nontoxic to zebrafish embryos. Overall, the cell cycle arrest, inhibition of Akt/Bad signal pathway, ROS generation and migration blocked might explain the potent anti-proliferative activities of these compounds.
Ternary Condensation of Aldehydes with Activated Nitriles and Cycloalkanones
Abdel-Latif, Fathy Fahim,Shaker, Rafat Mohamed
, p. 146 - 147 (2007/10/03)
Aromatic aldehydes condense with malononitrile or ethyl cyanoacetate and cycloalkanones in the presence of ammonium acetate to give a variety of carbocyclic and heterocyclic products, including pyridones.
