80681-26-1

Basic information

• Product Name: N²-isobutyryl-5'-O-monomethoxytrityl-2'-deoxy-2'-fluoroguanosine
• CAS NO: 80681-26-1
• Molecular Weight: 627.672
• Mol File: 80681-26-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N²-isobutyryl-5'-O-monomethoxytrityl-2'-deoxy-2'-fluoroguanosine(CAS DataBase Reference)
• NIST Chemistry Reference: N²-isobutyryl-5'-O-monomethoxytrityl-2'-deoxy-2'-fluoroguanosine(80681-26-1)
• EPA Substance Registry System: N²-isobutyryl-5'-O-monomethoxytrityl-2'-deoxy-2'-fluoroguanosine(80681-26-1)

Safety Data

• Hazardous Substances Data: 80681-26-1(Hazardous Substances Data)

Upstream product

• 78842-12-3 N²-isobutyryl-3'-O,5'-O-bis(tetrahydrofuranyl)-2'-deoxy-2'-fluoroguanosine 
• 80681-25-0 2’-fluoro-N2-isobutyryl-2’-deoxyguanosine 
• 14470-28-1 mono-4-methoxytrityl chloride 

Relevant articles and documents

Studies on Nucleosides and Nucleotides. LXXXVIII. Synthesis of a Non-hydrolyzable Substrate Analog of Ribonuclease Tl, 2'-Deoxy-2'-fluoroguanylyl-(3'-5')-uridine

2'-Deoxy-2'-fluoroguanylyl-(3'-5')-uridine (GfpU) was synthesized as a non-hydrolyzable substrate analog of ribonuclease T1. 2'-Deoxy-2'-fluoroguanosine was derivatized to the N2-isobutyryl-5''-monomethoxytrityl compound and condensed with 2',3'-di-O-acetyluridine 5'-monophosphate by the use of dicyclohexylcarbodiimide to obtain GfpU.For structural elucidation of the dinucleoside monophosphate, 2'-deoxy-2'-fluoroguanosine 3'-monophosphate was also synthesized.The conformation of GfpU was found to take a right-handed, weakly stacked form as deduced by ultraviolet, circular dichroism, and nuclear magnetic resonance (NMR) spectroscopy.Keywords--N2-isobutyryl-2'-deoxy-2'-fluoroguanosine; N2-isobutyltyl-5'-monomethoxytrityl-2'-deoxy-2'-fluoroguanosine; UV, CD, NMR, TLC; PPC