80688-36-4

Basic information

• Product Name: 2-(3,4-dimethylphenyl)-2-oxoacetaldehyde
• Synonyms: 2-(3,4-dimethylphenyl)-2-oxoacetaldehyde
• CAS NO: 80688-36-4
• Molecular Weight: 162.188
• Mol File: 80688-36-4.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: 2-(3,4-dimethylphenyl)-2-oxoacetaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3,4-dimethylphenyl)-2-oxoacetaldehyde(80688-36-4)
• EPA Substance Registry System: 2-(3,4-dimethylphenyl)-2-oxoacetaldehyde(80688-36-4)

Safety Data

• Hazardous Substances Data: 80688-36-4(Hazardous Substances Data)

Upstream product

• 2633-50-3 2-bromo-1-(3,4-dimethylphenyl)ethanone 
• 3637-01-2 3,4-dimethylacetophenone 
• 95-47-6 o-xylene 
• 109300-45-0 2,2-Dichloro-1-(3,4-dimethyl-phenyl)-ethanone 

Downstream Products

• 80120-32-7 ethyl 2-(3,4-dimethylphenyl)-2-oxoacetate 
• 619-04-5 3,4-dimethylbenzoic acid 
• 59411-15-3 1-(3,4-dimethylphenyl)-2-phenylethane-1,2-dione 
• 1267971-97-0 1-(3,4-dimethylphenyl)-2-(piperidin-1-yl)ethane-1,2-dione 
• 128863-46-7 3-methoxy-6-(2'-methoxyphenoxy)-2-(3,4-dimethylphenyl)imidazo<1,2-b>pyridazine 
• 121247-04-9 6-chloro-2-(3',4'-dimethylphenyl)-3-methoxyimidazo<1,2-b>pyridazine 

Relevant articles and documents

Direct preparation of indole hemiaminals through organocatalytic nucleophilic addition of indole to aldehydes

Hemiaminals are common in natural products as well as bioactive compounds. Hemiaminals with an indole moiety are particularly attractive due to the significant bioactivity of indoles. Herein, we reported an efficient organocatalyzed indole N-1 nucleophilic addition of α-oxoaldehydes to deliver various indole hemiaminals in good yields (up to 92percent) and excellent regioselectivities with DABCO or triethylamine as the catalyst. The method is characterized by mild reaction conditions, widely available reagents, and general substrate scope, and it is also applicable to late-stage transformations without affecting the hemiaminal group. In addition, we carried out this reaction in an enantioselective fashion in good yields and high ee values with two general substrates.

Visible-light assisted one-pot preparation of aryl glyoxals from acetoarylones via in-situ arylacyl bromides formation: Selenium-free approach to acetoarylones oxidation

A novel visible-light (blue LEDs: hν?=?425?±?15?nm) photocatalyzed one-pot method for the synthesis of electronically diverse aryl glyoxals in good to excellent yields from acetoarylones and green regents such as air, vitamin C and dioxane dibromide has been described. In addition, an application of the current methodology has been demonstrated for the oxidation of monoamine oxidase-B inhibitors, i.e., 1-(4-((4-fluorobenzyl)oxy)phenyl)ethanone and 1-(3-((4-chlorobenzyl)oxy)phenyl)ethanone. This finding may serves as a valuable alternative to the traditional acetoarylones oxidation reactions conducted using selenium dioxide a harmful and unselective reagent known to simultaneously oxidize allylic, benzylic, [sbnd]CH3and so on.

Metal-free oxidative amidation of 2-oxoaldehydes: A facile access to α-ketoamides

A novel and efficient method for the synthesis of α-ketoamides, employing a dimethyl sulfoxide (DMSO)-promoted oxidative amidation reaction between 2-oxoaldehydes and amines under metal-free conditions is presented. Furthermore, mechanistic studies supported an iminium ion-based intermediate as a central feature of reaction wherein C1-oxygen atom of α-ketoamides is finally derived from DMSO.