80719-70-6

Basic information

• Product Name: (4R,5S)-3-<(2S)-1-oxo-2,4-dimethylpent-4-enyl>-4-methyl-5-phenyloxazolidin-2-one
• Synonyms: (4R,5S)-3-<(2S)-1-oxo-2,4-dimethylpent-4-enyl>-4-methyl-5-phenyloxazolidin-2-one
• CAS NO: 80719-70-6
• Molecular Weight: 287.359
• Mol File: 80719-70-6.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: (4R,5S)-3-<(2S)-1-oxo-2,4-dimethylpent-4-enyl>-4-methyl-5-phenyloxazolidin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: (4R,5S)-3-<(2S)-1-oxo-2,4-dimethylpent-4-enyl>-4-methyl-5-phenyloxazolidin-2-one(80719-70-6)
• EPA Substance Registry System: (4R,5S)-3-<(2S)-1-oxo-2,4-dimethylpent-4-enyl>-4-methyl-5-phenyloxazolidin-2-one(80719-70-6)

Safety Data

• Hazardous Substances Data: 80719-70-6(Hazardous Substances Data)

Upstream product

• 3756-30-7 1-iodo-2-methyl-2-propene 
• 77877-20-4 (4R,5S)-4-methyl-5-phenyl-3-propionyloxazolidin-2-one 
• 1458-98-6 2-methyl-3-bromo-1-propene 
• 492-39-7 (1S,2S)-2-amino-1-phenylpropanol 
• 77943-39-6 4-methyl-5-phenyloxazolidin-2-one 

Downstream Products

• 107691-84-9 (2'R,3'S,4R,4'S,5S)-(+)-3-(2'-ethyl-3'-hydroxy-4',6'-dimethyl-1'-oxohept-6'-enyl)-4-methyl-5-phenyloxazolidin-2-one 
• 107691-84-9 (4R,5S)-3-((2S,3S,4S)-2-Ethyl-3-hydroxy-4,6-dimethyl-hept-6-enoyl)-4-methyl-5-phenyl-oxazolidin-2-one 
• 130514-53-3 C₃₆H₆₄O₃Si₃ 
• 107691-87-2 (2'R,3'S,4R,4'S,5S,6'R)-(-)-3-(7'-t-butyldimethylsilyloxy-2'-ethyl-4',6'-dimethyl-1'-oxo-3'-trimethylsilyloxyheptyl)-4-methyl-5-phenyloxazolidin-2-one 
• 130514-52-2 (2'R,2''S,3''S,4R,5S,5''R)-(+)-<2'-(3'',5''-dimethyl-6''-oxotetrahydropyran-2''-yl)-1'-oxobutyl>-4-methyl-5-phenyloxazolidin-2-one 
• 130514-51-1 (4R,5S)-3-[(R)-2-((2S,3S,5R)-6-Hydroxy-3,5-dimethyl-tetrahydro-pyran-2-yl)-butyryl]-4-methyl-5-phenyl-oxazolidin-2-one 
• 107691-86-1 (2'R,3'S,4R,4'S,5S,6'R)-(-)-3-(2'-ethyl-7'-hydroxy-4',6'-dimethyl-1'-oxo-3'-trimethylsilyloxyheptyl)-4-methyl-5-phenyloxazolidin-2-one 
• 130514-54-4 (1'S,3R,5S,6S)-(+)-6-<1'-(t-butyldiphenylsilyloxymethyl)propyl>-3,5-dimethyltetrahydropyran-2-one 
• 107691-85-0 (2'R,3'S,4R,4'S,5S)-(-)-3-(2'-ethyl-4',6'-dimethyl-1'-oxo-3'-trimethylsilyloxyhept-6'-enyl)-4-methyl-5-phenyloxazolidin-2-one 
• 130514-50-0 (2'R,3'S,4R,4'S,5S,6'R)-(+)-3-(2'-ethyl-3',7'-dihydroxy-4',6'-dimethyl-1'-oxoheptyl)-4-methyl-5-phenyloxazolidin-2-one 
• 130808-32-1 (2R,4S,5S,6S)-(+)-7-t-butyldiphenylsilyloxy-5-ethyl-2,4-dimethylheptane-1,5-diol 
• 82507-49-1 (4S,5S)-3-<(2R,3S,4S)-1-oxo-2,4,6-trimethyl-3-hydroxyhept-6-enyl>-4-methyl-5-phenyloxazolidin-2-one 
• 110838-51-2 benzyl (2S,3R,6S,7S,8S)-2,4,6,8-tetramethyl-3-<(trimethylsilyl)oxy>-7,9-((R)-naphthylmethylenedioxy)-1-nonanoate 
• 110815-00-4 benzyl (2S,3R,4R,6S,7S,8S)-2,4,6,8-tetramethyl-3,7,9-trihydroxy-1-nonanoate 

Relevant articles and documents

Thermal proteome profiling efficiently identifies ribosome destabilizing oxazolidinones

Identifying the targets of bioactive small molecules is a challenging endeavor for which no general solution currently exists. Classical affinity purification experiments suffer from the need to functionalise a bioactive compound and link it to a solid support, which may interfere with target binding. A modern mass spectrometry-based proteomics technique that has partially circumvented this problem is thermal proteome profiling (TPP), which determines the effect of an unmodified small molecule on the thermal stability of the whole proteome simultaneously. Here, we use TPP to identify the mode-of-action of a newly-discovered autophagy inhibitor based on oxazolidinones often employed as chiral auxiliaries. Surprisingly, a significant portion of all ribosomal proteins were found to be destabilized by the inhibitor, highlighting the utility of this technology for determining a challenging mode-of-action.

Synthetic studies in the lysocellin family of polyether antibiotics. The total synthesis of ferensimycin B

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Asymmetric Alkylation Reactions of Chiral Imide Enolates. A Practical Approach to the Enantioselective Synthesis of α-Substituted Carboxylic Acid Derivatives

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