80726-52-9Relevant articles and documents
3-methyl-hio-4-(5-, 6-, or 7-)phenylindolindolin-2-ones
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, (2008/06/13)
This invention relates to novel compounds having the formula: STR1 wherein; R1 is fluoro, chloro, bromo, lower-alkyl or nitro, R2 is lower alkyl, lower alkoxy, fluoro, chloro, bromo, nitro or trifluoromethyl, and m and n are 0-2 with the proviso that when R1 or R2 are tertiary butyl or a sterically hindering lower alkyl radical, m and/or n are 1. These compounds are intermediates in the preparation of 2-aminobiphenylacetic acids, esters and metal salts thereof.
Antiinflammatory Agents. 2. Syntheses and Antiinflammatory Activity of Substituted 2-Aminophenylacetic Acid Derivatives
Walsh, David A.,Shamblee, Dwight A.,Welstead, William J.,Sancilio, Lawrence F.
, p. 446 - 451 (2007/10/02)
Several substituted 2-aminophenylacetic acid derivatives were prepared and tested for in vitro prostaglandin synthetase inhibition and for in vivo antiinflammatory activity.The 2-amino substituent is beneficial to potency in the inhibition of prostaglandin synthetase for the 3-phenoxy, 4-phenyl, and 3-benzoyl series, but only 3-benzoyl series shows increased antiinflammatory potency in the in vivo assay.