80749-75-3

Basic information

• Product Name: 2-Propenoic acid, 3-(2,4,5-trimethoxyphenyl)-, methyl ester, (E)-
• CAS NO: 80749-75-3
• Molecular Formula: C13H16O5
• Molecular Weight: 252.267
• Mol File: 80749-75-3.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: 2-Propenoic acid, 3-(2,4,5-trimethoxyphenyl)-, methyl ester, (E)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propenoic acid, 3-(2,4,5-trimethoxyphenyl)-, methyl ester, (E)-(80749-75-3)
• EPA Substance Registry System: 2-Propenoic acid, 3-(2,4,5-trimethoxyphenyl)-, methyl ester, (E)-(80749-75-3)

Safety Data

• Hazardous Substances Data: 80749-75-3(Hazardous Substances Data)

Upstream product

• 2033-24-1 cycl-isopropylidene malonate 
• 4460-86-0 asaraldehyde 
• 67-56-1 methanol 
• 490-64-2 asaronic acid 
• 89337-61-1 tert-butyl((1-methoxyprop-1-en-1-yl)oxy)dimethylsilane 
• 292638-85-8 acrylic acid methyl ester 
• 99217-07-9 trans 2,4,5-trimethoxy cinnamaldehyde 
• 73490-49-0 (E)-3-(2,4,5-trimethoxyphenyl)prop-2-enoic acid 
• 79-22-1 methyl chloroformate 
• 21204-67-1 methyl (triphenylphosphoranylidene)acetate 

Downstream Products

• 20491-91-2 2,4,5-trimethoxyphenol 
• 24160-53-0 2,4,5-trimethoxycinnamic acid 
• 121587-97-1 (3α, 4β, 5α)-dihydro-5-(2,4,5-trimethoxyphenyl)-3,4-di(carboxymethyl)-2(3H)-furanone 
• 141341-75-5 dimethyl t-3,c-4-di-(2,4,5-trimethoxyphenyl)cyclobutane-r-1,t-2-dicarboxylate 
• 1392497-89-0 3-(2,4,5-trimethoxyphenyl)-(2E)-2-propen-1-ol 
• 264147-43-5 methyl 3-(2,4,5-trimethoxyphenyl)propanoate 

Relevant articles and documents

Synthesis, antiepileptic effects, and structure-activity relationships of α-asarone derivatives: In vitro and in vivo neuroprotective effect of selected derivatives

In the present study, we compared the antiepileptic effects of α-asarone derivatives to explore their structure-activity relationships using the PTZ-induced seizure model. Our research revealed that electron-donating methoxy groups in the 3,4,5-position on phenyl ring increased antiepileptic potency but the placement of other groups at different positions decreased activity. Besides, in allyl moiety, the optimal activity was reached with either an allyl or a 1-butenyl group in conjugation with the benzene ring. The compounds 5 and 19 exerted better neuroprotective effects against epilepsy in vitro (cell) and in vivo (mouse) models. This study provides valuable data for further exploration and application of these compounds as potential anti-seizure medicines.

a-ASARY-LALDEHYDE ESTER, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF

The present invention relates to α-asary-laldehyde ester, a preparation method therefor, and an application thereof. The chemical structure of the related α-asary-laldehyde ester is represented by formula I. A related application is an application of the compound in preparation of drugs for calming, mind tranquillizing, senile dementia resisting, convulsion resisting, epilepsy resisting and depression resisting.

Pd-catalyzed decarboxylative arylation of silyl enol ester sp3 β-C-H bond under aerobic conditions

Pd-catalyzed aerobic oxidative coupling of various benzoic acids with silyl enol esters proceeds via a combination of decarboxylation with sp3 β-C-H bond activation to give Heck-type products. Mechanistic studies reveal this coupling involves in situ generation of olefin from aerobic oxidation of silyl enolate, followed by decarboxylative Heck coupling.