80758-83-4

Basic information

• Product Name: (S)-11-ForMy-4-ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a -diaza-dibenzo[b,h]fluorene-3,13-dione
• Synonyms: (S)-11-ForMy-4-ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a -diaza-dibenzo[b,h]fluorene-3,13-dione
• CAS NO: 80758-83-4
• Molecular Formula: C₂₁H₁₆N₂O₅
• Molecular Weight: 376.36214
• Mol File: 80758-83-4.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 817°Cat760mmHg
• Flash Point: 447.9°C
• Appearance: /
• Density: 1.54g/cm³
• CAS DataBase Reference: (S)-11-ForMy-4-ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a -diaza-dibenzo[b,h]fluorene-3,13-dione(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-11-ForMy-4-ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a -diaza-dibenzo[b,h]fluorene-3,13-dione(80758-83-4)
• EPA Substance Registry System: (S)-11-ForMy-4-ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a -diaza-dibenzo[b,h]fluorene-3,13-dione(80758-83-4)

Safety Data

• Hazardous Substances Data: 80758-83-4(Hazardous Substances Data)

Usage

Description

(S)-11-ForMy-4-ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione is a complex organic compound characterized by its unique molecular structure. It features an ethyl group, a hydroxy group, and a dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione core. Although its chemical properties are not extensively documented, this compound may hold potential applications in various fields, including pharmaceuticals, organic chemistry, and material science. Further research and analysis are necessary to fully comprehend its properties and possible uses.

Uses

Used in Pharmaceutical Applications:
(S)-11-ForMy-4-ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione is used as a potential pharmaceutical agent for [application reason]. Its unique molecular structure may offer novel interactions with biological targets, potentially leading to the development of new therapeutics.
Used in Organic Chemistry Research:
In the field of organic chemistry, (S)-11-ForMy-4-ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione is used as a compound for [application reason], such as exploring new synthetic pathways or studying its reactivity with other molecules.
Used in Material Science:
(S)-11-ForMy-4-ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione is used as a component in the development of new materials for [application reason], possibly due to its unique structural features that could contribute to specific material properties.
Please note that the "application reason" for each use should be filled in based on the specific context or information available about the compound's properties and potential applications. The provided materials do not give specific reasons for its use in these fields, so further research would be required to determine the exact applications and benefits of (S)-11-ForMy-4-ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione.

Upstream product

• 78287-14-6 7-hydroxymethylcamptothecin 
• 84018-01-9 7-Ethoxymethylcamptothecin 
• 64-19-7 acetic acid 
• 80735-03-1 7-methoxycamptothecin 
• 103-80-0 phenylacetyl chloride 
• 7689-03-4 camptothecin 
• 67-56-1 methanol 
• 84017-99-2 7-(dimethoxymethyl)camptothecin 

Downstream Products

• 84018-05-3 (S)-4-Ethyl-4-hydroxy-11-(phenyl-hydrazonomethyl)-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione 
• 292618-32-7 gimatecan 
• 372105-27-6 anti-7-(2-aminoethoxy)iminomethylcamptothecin 

Relevant articles and documents

Synthesis, biological activities, and quantitative structure-Activity relationship (QSAR) Study of novel camptothecin analogues

In continuation of our program aimed at the development of natural product-based pesticidal agents, three series of novel camptothecin derivatives were designed, synthesized, and evaluated for their biological activities against T. Cinnabarinus, B. brassicae, and B. xylophilus. All of the derivatives showed good-To-excellent activity against three insect species tested, with LC50 values ranging from 0.00761 to 0.35496 mmol/L. Remarkably, all of the compounds were more potent than CPT against T. Cinnabarinus, and compounds 4d and 4c displayed superior activity (LC50 0.00761 mmol/L and 0.00942 mmol/L, respectively) compared with CPT (LC50 0.19719 mmol/L) against T. Cinnabarinus. Based on the observed bioactivities, preliminary structure activity relationship (SAR) correlations were also discussed. Furthermore, a three-dimensional quantitative structure activity relationship (3D-QSAR) model using comparative molecular field analysis (CoMFA) was built. The model gave statistically significant results with the cross-validated q2 values of 0.580 and correlation coefficient r2 of 0.991 and 2 pred r of 0.993. The QSAR analysis indicated that the size of the substituents play an important in the activity of 7-modified camptothecin derivatives. These findings will pave the way for further design, structural optimization, and development of camptothecin-derived compounds as pesticidal agents.

CRYSTALLINE FORM II OF 7-(DIMETHOXY-METHYL) CAMPTOTHECIN, ITS USE AS INTERMEDIATE AND PRODUCTS OBTAINED THEREFROM

This invention relates to a process for preparing a crystalline form of (4S)-11-(dimethoxymethyl)-4-ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]qui-no line-3,14(4H,12H)-dione (also named 7-(dimethoxy-methyl)camptothecin). With the provision of a particular crystallization step, in appropriate way, a new crystalline form of the above compound is obtained. The process for the preparation of the polymorph Form II comprises transforming camptothecin to the corresponding 7-(dimethoxy-methyl)-camptothecin, and crystallizing it from methanol.

CHEMICAL MODIFICATION OF ANTITUMOR ALKALOID CAMPTOTHECIN. ACID-CATALYZED CONVERSION OF 7-HYDROXYMETHYLCAMPTOTHECIN INTO THE ALDEHYDE AND ITS ACETALS

Camptothecin-7-carbaldehyde (3) was prepared from 7-hydroxymethylcamptothecin (2) by treatment with such cationoid agent as sulfuric acid, acetic acid, p-toluenesulfonyl chloride, phosphoryl chloride, thionyl chloride, or triphenylphosphinecarbon tetrachloride.On heating with sulfuric acid in an alcoholic solution, 2 afforded 7-alkoxymethylcamptothecin (4) and 7-dialkoxymethylcamptothecin (5), the product-ratio depending upon the acid-concentration.