808134-96-5

Basic information

• Product Name: Oxazole, 2-[1-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-7-phenylheptyl]-
• CAS NO: 808134-96-5
• Molecular Formula: C22H35NO2Si
• Molecular Weight: 373.611
• Mol File: 808134-96-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Oxazole, 2-[1-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-7-phenylheptyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Oxazole, 2-[1-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-7-phenylheptyl]-(808134-96-5)
• EPA Substance Registry System: Oxazole, 2-[1-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-7-phenylheptyl]-(808134-96-5)

Safety Data

• Hazardous Substances Data: 808134-96-5(Hazardous Substances Data)

Upstream product

• 121784-15-4 7-phenylheptanal 
• 808134-95-4 1-(oxazol-2-yl)-7-phenylheptan-1-ol 
• 18162-48-6 tert-butyldimethylsilyl chloride 

Downstream Products

• 914482-92-1 1-{2-[1-(tert-butyldimethylsilyloxy)-7-phenylheptyl]oxazol-5-yl}ethanone 
• 914482-90-9 2-[1-(tert-butyldimethylsilyloxy)-7-phenylheptyl]oxazole-5-carboxylic acid 
• 1010398-28-3 2-(1-(tert-butyldimethylsilyloxy)-7-phenylheptyl)-5-(trifluoromethylsulfonyl)oxazole 

Relevant articles and documents

Delineation of a fundamental α-ketoheterocycle substituent effect for use in the design of enzyme inhibitors

The synthesis and examination of a systematic series of 5-substituted 2-keto oxazoles as inhibitors of fatty acid amide hydrolase (FAAH) defined a fundamental substituent effect that led to the discovery of inhibitors with Ki's as low as 400 pM. The intrinsic basis of the relationship (-log Ki vs σp), which relates Ki with the Hammett σp constant of the substituent, the magnitude of the effect (ρ = 3.01), and its predictive value (R2 = 0.91) suggest a widespread applicability in studies beyond FAAH. Copyright