80830-66-6

Basic information

• Product Name: 2-Benzylamino-4-phenylpyrimidine
• CAS NO: 80830-66-6
• Molecular Weight: 261.326
• Mol File: 80830-66-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-Benzylamino-4-phenylpyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Benzylamino-4-phenylpyrimidine(80830-66-6)
• EPA Substance Registry System: 2-Benzylamino-4-phenylpyrimidine(80830-66-6)

Safety Data

• Hazardous Substances Data: 80830-66-6(Hazardous Substances Data)

Upstream product

• 588-46-5 N-(phenylmethyl)acetamide 
• 14161-40-1 4-phenylpyrimidine-1-oxide 
• 3438-48-0 4-phenylpyrimidine 
• 100-52-7 benzaldehyde 
• 2305-87-5 4-phenylpyrimidin-2-amine 

Relevant articles and documents

C2-Selective, Functional-Group-Divergent Amination of Pyrimidines by Enthalpy-Controlled Nucleophilic Functionalization

Synthesis of heteroaryl amines has been an important topic in organic chemistry because of their importance in small-molecule discovery. In particular, 2-Aminopyrimidines represent a highly privileged structural motif that is prevalent in bioactive molecules, but a general strategy to introduce the pyrimidine C2-N bonds via direct functionalization is elusive. Here we describe a synthetic platform for site-selective C-H functionalization that affords pyrimidinyl iminium salt intermediates, which then can be transformed into various amine products in situ. Mechanism-based reagent design allowed for the C2-selective amination of pyrimidines, opening the new scope of site-selective heteroaryl C-H functionalization. Our method is compatible with a broad range of pyrimidines with sensitive functional groups and can access complex aminopyrimidines with high selectivity.