80875-87-2

Basic information

• Product Name: 2'-DEOXYADENOSINE-5'-O-(1-THIOTRIPHOSPHATE), RP-ISOMER SODIUM SALT
• Synonyms: 2'-DEOXYADENOSINE-5'-O-(1-THIOTRIPHOSPHATE), SP-ISOMER SODIUM SALT;2'-DEOXYADENOSINE-5'-O-(1-THIOTRIPHOSPHATE), RP-ISOMER SODIUM SALT;RP-DATP-ALPHA-S SODIUM SALT;SP-DATP-ALPHA-S SODIUM SALT;2’-deoxyadenosine-5’-o-(1-thiotriphosphate),sp-isomer(sp-datp-@-s),sodiumsalt;2''-Deoxyadenosine-5''-O-(1-thiotriphosphoric acid) Sp-isomer
• CAS NO: 80875-87-2
• Molecular Formula: C10H12N5Na4O11P3S
• Molecular Weight: 595.17
• Mol File: 80875-87-2.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 903.5 °C at 760 mmHg
• Flash Point: 500.2 °C
• Appearance: /
• Density: 2.45 g/cm³
• CAS DataBase Reference: 2'-DEOXYADENOSINE-5'-O-(1-THIOTRIPHOSPHATE), RP-ISOMER SODIUM SALT(CAS DataBase Reference)
• NIST Chemistry Reference: 2'-DEOXYADENOSINE-5'-O-(1-THIOTRIPHOSPHATE), RP-ISOMER SODIUM SALT(80875-87-2)
• EPA Substance Registry System: 2'-DEOXYADENOSINE-5'-O-(1-THIOTRIPHOSPHATE), RP-ISOMER SODIUM SALT(80875-87-2)

Safety Data

• Hazardous Substances Data: 80875-87-2(Hazardous Substances Data)

Upstream product

• 25152-96-9 N⁶-benzoyl-3'-(methoxyacetyl)-2'-deoxyadenosine 
• 118275-89-1 C₂₀H₂₀N₅O₁₃P₃S^(2-) 

Relevant articles and documents

Rapid and Efficient Synthesis of Nucleoside 5'-O-(1-Thiotriphosphates), 5'-Triphosphates and 2',3'-Cyclophosphorothioates Using 2-Chloro-4H-1,3,2-benzodioxaphosphorin-4-one

2-Chloro-4H-1,3,2-benzodioxaphosphorin-4-one phosphitylates the 5'-hydroxy group of a nucleoside to form an intermediate (2), which on subsequent reaction with pyrophosphate produces, in a double displacement process, a P2,P3-dioxo-P1-5'-nucleosidylcyclotriphophite (3).Oxidation with sulfur gives a nucleoside 5'-(1-thiocyclotriphosphate) (4), which is hydrolyzed to the diastereomeric mixture of a nucleoside 5'-O-(1-thiotriphosphate) (5).Alternatively, 3 can be oxidized with iodine/water to furnish nucleoside 5'-triphosphates 6.This reagent can also be applied to the synthesis of nucleoside 2',3'-cyclic phosphorothioates.Protection of nucleobase functional groups is not required.