808771-17-7Relevant articles and documents
Synthesis of the C7-26 fragment of amphidinolides G and H
Hara, Akihiro,Morimoto, Ryo,Ishikawa, Yuichi,Nishiyama, Shigeru
, p. 4036 - 4039 (2011)
A new approach to the synthesis of the C7-26 fragment of amphidinolides G and H was developed. In the sequence, the C7-18 portion of this fragment was synthesized using an acetylide coupling protocol, while an Evans alkylation and Sharpless asymmetric dihydroxylation were employed as key steps in construction of the C19-26 subfragment. Finally, both of these units were joined by utilizing an aldol coupling reaction to produce the target C7-26 fragment in good yield.