80882-52-6

Basic information

• Product Name: 2-(dimethylamino)isonicotinonitrile
• Synonyms: 2-(dimethylamino)isonicotinonitrile
• CAS NO: 80882-52-6
• Molecular Formula: C₈H₉N₃
• Molecular Weight: 147.17716
• Mol File: 80882-52-6.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-(dimethylamino)isonicotinonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(dimethylamino)isonicotinonitrile(80882-52-6)
• EPA Substance Registry System: 2-(dimethylamino)isonicotinonitrile(80882-52-6)

Safety Data

• Hazardous Substances Data: 80882-52-6(Hazardous Substances Data)

Usage

General Description

2-(dimethylamino)isonicotinonitrile is a chemical compound with the molecular formula C8H9N3. It is a derivative of isonicotinonitrile, and it contains a dimethylamino group attached to the second carbon of the pyridine ring. 2-(dimethylamino)isonicotinonitrile is commonly used in organic synthesis as a building block for the preparation of various pharmaceuticals and agrochemicals. It is also used as a reagent in the synthesis of heterocyclic compounds and as a precursor for the preparation of various functionalized molecules. 2-(dimethylamino)isonicotinonitrile is known for its ability to participate in a variety of chemical reactions, making it a versatile and valuable tool in the field of organic chemistry.

Upstream product

• 33252-30-1 2-chloro-4-pyridinenitrile 
• 124-40-3 dimethyl amine 

Downstream Products

• 80882-55-9 1-(2-N,N-dimethylamino-4-pyridyl)-1-ethanone oxime O-tosylate 
• 1016772-06-7 2-methylaminothioisonicotinamide 
• 1260433-27-9 4-((3-chlorophenyl)(imino)methyl)-N,N-dimethylpyridin-2-amine 
• 1260432-45-8 4-(4-amino-2-(3'-methoxybiphenyl-3-yl)-5-methyl-2H-imidazol-2-yl)-N,N-dimethylpyridin-2-amine 
• 1260433-28-0 4-(4-amino-2-(3-chlorophenyl)-5-methyl-2H-imidazol-2-yl)-N,N-dimethylpyridin-2-amine 

Relevant articles and documents

Acridone-based inhibitors of inosine 5′-monophosphate dehydrogenase: Discovery and SAR leading to the identification of N-(2-(6-(4-ethylpiperazin-1- yl)pyridin-3-yl)propan-2-yl)-2-fluoro-9-oxo-9,10-dihydroacridine-3-carboxamide (BMS-566419)

Inosine monophosphate dehydrogenase (IMPDH), a key enzyme in the de novo synthesis of guanosine nucleotides, catalyzes the irreversible nicotinamide-adenine dinucleotide dependent oxidation of inosine-5′- monophosphate to xanthosine-5′-monophosphate. Mycophenolate Mofetil (MMF), a prodrug of mycophenolic acid, has clinical utility for the treatment of transplant rejection based on its inhibition of IMPDH. The overall clinical benefit of MMF is limited by what is generally believed to be compound-based, dose-limiting gastrointestinal (GI) toxicity that is related to its specific pharmacokinetic characteristics. Thus, development of an IMPDH inhibitor with a novel structure and a different pharmacokinetic profile may reduce the likelihood of GI toxicity and allow for increased efficacy. This article will detail the discovery and SAR leading to a novel and potent acridone-based IMPDH inhibitor 4m and its efficacy and GI tolerability when administered orally in a rat adjuvant arthritis model.