80885-47-8Relevant articles and documents
ENANTIOSELECTIVE SYNTHESIS OF C3-C10 FRAGMENT (NORTHEASTERN ZONE) OF MAYTANSINOIDS WITH 4-CHIRAL CENTERS (4S,5S,6R,7S)
Meyers, A. I.,Hudspeth, James P.
, p. 3925 - 3928 (1981)
The major precursor to the maytansinoids containing 4 non-racemic chiral centers has been prepared in gram quantities, suitable for further synthesis.The route to (+)-1 was accomplished in 13 steps including several highly stereocontrolled reactions which