80945-68-2

Basic information

• Product Name: 2(3H)-Benzothiazolone,4-nitro-,hydrazone(9CI)
• Synonyms: 2(3H)-Benzothiazolone,4-nitro-,hydrazone(9CI)
• CAS NO: 80945-68-2
• Molecular Formula: C₇H₆N₄O₂S
• Molecular Weight: 210.21
• Product Categories: BENZOTHIAZOLE
• Mol File: 80945-68-2.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2(3H)-Benzothiazolone,4-nitro-,hydrazone(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2(3H)-Benzothiazolone,4-nitro-,hydrazone(9CI)(80945-68-2)
• EPA Substance Registry System: 2(3H)-Benzothiazolone,4-nitro-,hydrazone(9CI)(80945-68-2)

Safety Data

• Hazardous Substances Data: 80945-68-2(Hazardous Substances Data)

Usage

Structure

2(3H)-Benzothiazolone,4-nitro-,hydrazone(9CI) is a hydrazone derivative of 2(3H)-benzothiazolone and contains a nitro group (The structure of 2(3H)-Benzothiazolone,4-nitro-,hydrazone(9CI) includes a benzothiazole ring, a nitro group, and a hydrazone functional group)

Applications

2(3H)-Benzothiazolone,4-nitro-,hydrazone(9CI) has potential applications in various fields including pharmaceuticals, agrochemicals, and materials science (The potential applications of 2(3H)-Benzothiazolone,4-nitro-,hydrazone(9CI) are diverse and include the use in the development of pharmaceuticals, agrochemicals, and materials)

Building block

2(3H)-Benzothiazolone,4-nitro-,hydrazone(9CI) is suitable for use as a building block in the synthesis of other organic compounds (The structure and properties of 2(3H)-Benzothiazolone,4-nitro-,hydrazone(9CI) make it a useful building block in the synthesis of other organic compounds)

Biological activities

2(3H)-Benzothiazolone,4-nitro-,hydrazone(9CI) may have specific biological activities and could be explored for potential therapeutic or pesticidal purposes (2(3H)-Benzothiazolone,4-nitro-,hydrazone(9CI) may have specific biological activities that could be useful in the development of therapeutic or pesticidal agents)

Upstream product

• 6973-51-9 2-amino-4-nitrobenzothiazole 
• 88-74-4 2-nitro-aniline 

Downstream Products

• 1246493-46-8 3-(3-pyridyl)-5-(4-methylphenyl)-4-(N-(4-nitro-1,3-benzothiazol-2-yl)amino)-4H-1,2,4-triazole 
• 1268376-13-1 3-(3-pyridyl)-5-(4-methoxyphenyl)-4-(N-4-nitro-1,3-benzothiazol-2-amino)-4H-1,2,4-triazole 
• 1316270-47-9 C₂₀H₁₂N₈O₄S 

Relevant articles and documents

Synthesis of 1,2,4-triazole derivatives containing benzothiazoles as pharmacologically active molecule

In attempt to make significant pharmacologically active molecule, we report here the synthesis and in vitro antimicrobial and antitubercular activity of various series of 3-(3-pyridyl)-5-(4-nitrophenyl)-4-(N-substituted-1,3- benzothiazol-2-amino)-4H-1,2,4-triazole. The antimicrobial activity of title compounds were examined against two Gram-positive bacteria (Staphylococcus aureus, Streptococcus pyogenes), two Gram-negative bacteria (Escherichia coli, Pseudomonas aeruginosa), and three fungi (Candida albicans, Aspergillus niger, Aspergillus clavatus) using the broth microdilution method and antitubercular activity H37Rv using Lowenstein-Jensen agar method.

Pharmacological evaluation and characterizations of newly synthesized 1,2,4-triazoles

The triazole analogs were obtained via. multistep synthesis sequence beginning with ethyl nicotinoate 3 which on treatment with hydrazine hydrate yields nicotinoyl hydrazide 4. Intermolecular cyclisation of 4 with 4-methylbenzoic acid in presence of phosphorous oxy chloride affords 2-(3-pyridyl)-5-(4-methylphenyl)-1,3,4-oxadiazole 5. Condensation of 5 with various substituted 2-hydrazino benzothiazole 2a-j results in 3-(3-pyridyl)-5-(4-methylphenyl)-4-(N-substituted-1,3-benzothiazol-2-amino) -4H-1,2,4-triazole 6a-j analogs. All the compounds have been characterized by elemental analysis, IR, 1H NMR, 13C NMR and mass spectral data. In vitro antitubercular activity was carried out against Mycobacterium tuberculosis H37Rv strain using Lowenstein-Jensen medium and antimicrobial activity against various bacteria and fungi using broth microdilution method. Compounds 2e, 6a, 6b, 6c, 6d, 6g, 6h and 6i emerged as promising antimicrobials. It was also observed that the promising antimicrobials have proved to be better antituberculars. Compound 6j showed better antitubercular activity compared to rifampicin. 3-(3-Pyridyl)-5-(4-methylphenyl) -4-(N-substituted-1,3-benzothiazol-2-amino)-4H-1,2,4-triazole 6a-j were synthesized and their antitubercular activity against H37Rv and antimicrobial activities have been tested.