80951-75-3

Basic information

• Product Name: 2'-DEOXYCYTIDINE-5'-O-(1-THIOTRIPHOSPHATE), RP-ISOMER SODIUM SALT
• Synonyms: 2'-DEOXYCYTIDINE-5'-O-(1-THIOTRIPHOSPHATE), RP-ISOMER SODIUM SALT;2'-DEOXYCYTIDINE-5'-O-(1-THIOTRIPHOSPHATE), SP-ISOMER SODIUM SALT;RP-DCTP-ALPHA-S SODIUM SALT;SP-DCTP-ALPHA-S SODIUM SALT;2’-deoxycytidine-5’-o-(1-thiotriphosphate),sp-isomer(sp-dctp-alpha-s),sodiumsalt;2'-Deoxycytidine 5'-P''-ester with thiotriphosphoric acid
• CAS NO: 80951-75-3
• Molecular Formula: C9H12N3Na4O12P3S
• Molecular Weight: 571.15
• Mol File: 80951-75-3.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 769.5±70.0 °C(Predicted)
• Appearance: /
• Density: 2.33±0.1 g/cm3(Predicted)
• PKA: 0.68±0.50(Predicted)
• CAS DataBase Reference: 2'-DEOXYCYTIDINE-5'-O-(1-THIOTRIPHOSPHATE), RP-ISOMER SODIUM SALT(CAS DataBase Reference)
• NIST Chemistry Reference: 2'-DEOXYCYTIDINE-5'-O-(1-THIOTRIPHOSPHATE), RP-ISOMER SODIUM SALT(80951-75-3)
• EPA Substance Registry System: 2'-DEOXYCYTIDINE-5'-O-(1-THIOTRIPHOSPHATE), RP-ISOMER SODIUM SALT(80951-75-3)

Safety Data

• Hazardous Substances Data: 80951-75-3(Hazardous Substances Data)

Upstream product

• 142730-06-1 N⁴-benzoyl-3'-(methoxyacetyl)-2'-deoxycytidine 
• 118275-92-6 C₁₉H₂₀N₃O₁₄P₃S^(2-) 

Relevant articles and documents

Rapid and Efficient Synthesis of Nucleoside 5'-O-(1-Thiotriphosphates), 5'-Triphosphates and 2',3'-Cyclophosphorothioates Using 2-Chloro-4H-1,3,2-benzodioxaphosphorin-4-one

2-Chloro-4H-1,3,2-benzodioxaphosphorin-4-one phosphitylates the 5'-hydroxy group of a nucleoside to form an intermediate (2), which on subsequent reaction with pyrophosphate produces, in a double displacement process, a P2,P3-dioxo-P1-5'-nucleosidylcyclotriphophite (3).Oxidation with sulfur gives a nucleoside 5'-(1-thiocyclotriphosphate) (4), which is hydrolyzed to the diastereomeric mixture of a nucleoside 5'-O-(1-thiotriphosphate) (5).Alternatively, 3 can be oxidized with iodine/water to furnish nucleoside 5'-triphosphates 6.This reagent can also be applied to the synthesis of nucleoside 2',3'-cyclic phosphorothioates.Protection of nucleobase functional groups is not required.