81-07-2Relevant articles and documents
Synthesis, characterization and antimicrobial evaluation of new 3-(Alkyl/Arylamino)benzo[d]isothiazole 1,1-derivatives
Kamble, Dhanraj P.,Shankarwar, Anil G.,Mane, Yogesh D.,Tigote, Radhakrishna M.,Sarnikar, Yuvaraj P.,Madje, Balaji R.
, p. 797 - 804 (2021/09/08)
The saccharine nucleus has long been recognized as a significant component in medicine. A series of pseudo-saccharine amines derivatives (7a-j) were synthesized and examined for their antibacterial activity. After testing all compounds, 7b, 7f, 7g, 7i and 7j were found most effective against Escherichia coli, Streptococcus aureus and Bacillus subtilis strains. The MIC of the compound was found from 4.6 to 16.1 μM. Further, compound 7f and 7i exhibited excellent activity against E.coli and Bacillus subtilis with MIC value 4.6 and 4.7 μM respectively. The compound 7b and 7i was found active against all the three bacteria. The zone inhibition was observed at 10 μM against Escherichia coli, Staphylococcus aureus and Bacillus subtilis at 0.9, 1.8, 3.9 respectively for 7b and 1.0, 1.8 and 2.0 cm respectively for 7i.
Preparation method of saccharin
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Paragraph 0128-0137; 0140-0151, (2020/10/14)
The invention discloses a preparation method of saccharin. The invention provides a preparation method of saccharin as shown in a formula 1 represented in the specification. The preparation method ischaracterized by comprising the following step: in water, in the presence of tungstate and/or tungstic acid, carrying out oxidation reaction on a compound shown in a formula 2 and hydrogen peroxide toobtain saccharin shown in a formula 1.
Method for removing saccharin in probenazole
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Paragraph 0018-0027, (2020/02/17)
The invention provides a method for removing saccharin in probenazole. The method comprises the steps: the probenazole containing saccharin impurities is suspended in an appropriate amount of water, then sodium bicarbonate or potassium bicarbonate is continuously added till no gas is generated, then centrifuge dripping is conducted, drip washing is conducted through an appropriate amount of water,and thus the saccharin in the probenazole can be removed. A water solution containing saccharin sodium is acidized, and then the saccharin can be recovered. The method is easy and convenient to operate, an organic solvent is not adopted, the three wastes (waste gas, waste water and industrial residue) are less, safety and environmental protection are achieved, an obtained product is high in purity, the production cost and the environmental protection cost are greatly saved, and industrialization is easy to achieve.