81016-49-1

Basic information

• Product Name: 5-Methyl-4-nitro-2H-pyrazole-3-carboxylic acid N'-(2-methoxy-phenyl)-hydrazide
• Synonyms: 5-Methyl-4-nitro-2H-pyrazole-3-carboxylic acid N'-(2-methoxy-phenyl)-hydrazide
• CAS NO: 81016-49-1
• Molecular Weight: 291.266
• Mol File: 81016-49-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 5-Methyl-4-nitro-2H-pyrazole-3-carboxylic acid N'-(2-methoxy-phenyl)-hydrazide(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Methyl-4-nitro-2H-pyrazole-3-carboxylic acid N'-(2-methoxy-phenyl)-hydrazide(81016-49-1)
• EPA Substance Registry System: 5-Methyl-4-nitro-2H-pyrazole-3-carboxylic acid N'-(2-methoxy-phenyl)-hydrazide(81016-49-1)

Safety Data

• Hazardous Substances Data: 81016-49-1(Hazardous Substances Data)

Upstream product

• 80030-73-5 2,7-dimethyl-3,8-dinitrodipyrazolo[1,5-a;1',5'-d]pyrazine-4,9-dione 
• 6971-45-5 2-methoxyphenylhydrazine hydrochloride 

Downstream Products

• 81016-61-7 6-(2-Methoxy-phenylamino)-3-methyl-1,6-dihydro-pyrazolo[4,3-d]pyrimidin-7-one 
• 81016-55-9 4-Amino-5-methyl-2H-pyrazole-3-carboxylic acid N'-(2-methoxy-phenyl)-hydrazide 

Relevant articles and documents

1H-pyrazolo[2,3-d][1,2,4]triazine-3,7-diones as a new class of Human Leukocyte Elastase inhibitors

A novel series of 1H-2-phenyl-substituted-pyrazolo[2,3- d][l,2,4]triazine-3,7-diones (3a-g) as potential inhibitors of Human Leukocyte Elastase (HLE) are reported, the acyl-pyrazole being probably involved in the inhibition mechanism of the serino-protease enzymes. The most potent inhibitor both in vivo and in vitro was 2-o-methoxyphenyl-5-methyl-6- nitro-pyrazolo[2,3-d][1,2,4]triazine-3,7-dione (3e), which significantly suppressed the HLE-induced pulmonary injury in rats when administered orally (100 mg/kg, 3 h prior to HLE administration.