81036-82-0

Basic information

• Product Name: 4-(4-bromophenyl)butyraldehyde
• Synonyms: 4-(4-bromophenyl)butyraldehyde
• CAS NO: 81036-82-0
• Molecular Weight: 227.101
• Mol File: 81036-82-0.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 4-(4-bromophenyl)butyraldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-bromophenyl)butyraldehyde(81036-82-0)
• EPA Substance Registry System: 4-(4-bromophenyl)butyraldehyde(81036-82-0)

Safety Data

• Hazardous Substances Data: 81036-82-0(Hazardous Substances Data)

Upstream product

• 108-30-5 succinic acid anhydride 
• 108-86-1 bromobenzene 
• 2294-43-1 1-allyl-4-bromo-benzene 
• 64-18-6 formic acid 
• 589-15-1 1-bromomethyl-4-bromobenzene 
• 75906-36-4 4-(p-bromophenyl)-butan-1-ol 
• 59099-79-5 4-(4-bromophenyl)-3-butyn-1-ol 
• 98453-57-7 4-(4-bromophenyl)butanoic acid methyl ester 
• 35656-89-4 4-(4-bromophenyl)butanoic acid 

Downstream Products

• 81036-83-1 4-(p-tolyl)butanal 
• 134336-90-6 1-bromo-4-(pent-4-en-1-yl)benzene 

Relevant articles and documents

Rhodium-Catalyzed Remote C(sp3)?H Borylation of Silyl Enol Ethers

A rhodium-catalyzed remote C(sp3)?H borylation of silyl enol ethers (SEEs, E/Z mixtures) by alkene isomerization and hydroboration is reported. The reaction exhibits mild reaction conditions and excellent functional-group tolerance. This method is compatible with an array of SEEs, including linear and branched SEEs derived from aldehydes and ketones, and provides direct access to a broad range of structurally diverse 1,n-borylethers in excellent regioselectivities and good yields. These compounds are precursors to various valuable chemicals, such as 1,n-diols and aminoalcohols.

Design, organocatalytic synthesis, and bioactivity evaluation of enantiopure fluorinated LpxC inhibitors

Enantiopure compounds with a strategically incorporated fluorine atom intended to enhance LpxC inhibition have been synthesized using an organocascade fluorination reaction as the key step. These are the first low molecular weight LpxC inhibitors to contain a fluorine atom on a critically important chiral center that is substituted with two pharmacophoric moieties, and were thusly designed to provide new SAR data for this class of compounds. Fluorinated compounds were evaluated against ESKAPE pathogens and exhibited MICs of ≤12.5 μg mL-1 against Pseudomonas aeruginosa.

Catalytic Oxygenative Allylic Transposition of Alkenes into Enones with an Azaadamantane-Type Oxoammonium Salt Catalyst

The first catalytic oxygenative allylic transposition of unactivated alkenes into enones has been developed using an oxoammonium salt as the catalyst. This reaction converts various tri- and trans-disubstituted alkenes into their corresponding enones with transposition of their double bonds at ambient temperature in good yields. The use of a less-hindered azaadamantane-type oxoammonium salt as the catalyst and a combination of two distinct stoichiometric oxidants, namely, iodobenzene diacetate and magnesium monoperoxyphthalate hexahydrate (MMPP?6 H2O) are essential to facilitate the enone formation efficiently.